多囊卵巢患者外周儿茶酚胺代谢产物与月经不调
Peripheral catecholamine metabolites and menstrual irregularity in patients with polycystic ovaries.
作者信息
Yoshino K, Takahashi K, Eda Y, Nishigaki A, Kitao M
机构信息
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
出版信息
Int J Fertil Menopausal Stud. 1993 Jul-Aug;38(4):225-8.
OBJECTIVE
To investigate the catecholamine status of patients with polycystic ovary syndrome.
DESIGN
Three parallel groups with polycystic ovary were diagnosed by ultrasound: (a) 5 patients with regularly ovulatory menstruation; (b) 10 with anovulatory menstruation; (c) 13 with secondary amenorrhea who responded to progestagen with withdrawal bleeding. Blood samples for measurement of LH, testosterone, and catecholamine metabolites were drawn during cycle days 4-7.
RESULTS
(1) Serum LH and testosterone of the patient groups (b) and (c) were significantly higher than those of controls. (2) Plasma 3,4-dihydroxyphenylglycol (DOPEG) and the DOPEG/DOPAC ratio were elevated in patients, and DOPAC levels were reduced. However, there was no significant difference of catecholamine metabolites among the three patient groups.
CONCLUSIONS
The androgen status in polycystic ovary diagnosed by ultrasound is correlated, but catecholamine status is not correlated, with the menstrual irregularity of polycystic ovary syndrome.
目的
研究多囊卵巢综合征患者的儿茶酚胺状态。
设计
通过超声诊断出三组多囊卵巢平行组：（a）5例月经周期规律且有排卵的患者；（b）10例无排卵性月经患者；（c）13例继发性闭经且对孕激素有撤退性出血反应的患者。在月经周期第4 - 7天采集血样，用于检测促黄体生成素（LH）、睾酮和儿茶酚胺代谢产物。
结果
（1）（b）组和（c）组患者的血清LH和睾酮显著高于对照组。（2）患者血浆3,4 - 二羟基苯乙二醇（DOPEG）和DOPEG/二羟基苯乙酸（DOPAC）比值升高，DOPAC水平降低。然而，三组患者之间儿茶酚胺代谢产物无显著差异。
结论
超声诊断的多囊卵巢患者的雄激素状态与多囊卵巢综合征的月经不规律相关，但儿茶酚胺状态与之无关。
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