从 D-木糖合成 1,4-二脱氧-1,4-亚氨基庚糖醇和 1,5-二脱氧-1,5-亚氨基辛糖醇。
Synthesis of 1,4-dideoxy-1,4-iminoheptitol and 1,5-dideoxy-1,5-iminooctitols from D-xylose.
机构信息
Department of Chemistry, Indian Institute of Technology, Kanpur, India.
出版信息
Carbohydr Res. 2010 Jun 16;345(9):1142-8. doi: 10.1016/j.carres.2010.04.016. Epub 2010 Apr 21.
PMID:20457450
Abstract
The synthesis of iminosugars from inexpensive D-xylose in high yields has been developed. The key step in this synthesis involves Wittig olefination or chelation-controlled attack of Grignard reagents on lactol and ring-closing metathesis using first or second generation Grubbs' catalysts.
摘要
已开发出从廉价的 D-木糖高产合成亚氨基糖的方法。该合成中的关键步骤包括 Wittig 烯化或螯合控制的格氏试剂对内酯的加成以及使用第一代或第二代 Grubbs 催化剂进行闭环复分解。
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