Department of Clinical Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
Vet J. 2011 May;188(2):216-20. doi: 10.1016/j.tvjl.2010.04.007. Epub 2010 May 8.
A retrospective study was conducted to determine the relationship between serum non-esterified fatty acids (NEFA), β-hydroxybutyrate (BHBA), glucose and calcium (Ca) with the occurrence of displaced abomasum (DA), clinical ketosis and culling in Holstein cows. Eight hundred and forty-nine cows from 16 farms were sampled weekly for the first 3 weeks post-partum. The cows were under clinical observation from calving until 60 days in milk (DIM) and during this time there were 22 cases of DA, 31 cases of clinical ketosis and 39 cows were culled. Elevated concentrations of BHBA were associated with DA, clinical ketosis and culling. In the first week after calving, cows with serum BHBA ≥1000μmol/L had 13.6 times greater odds of developing DA than cows with lower values. Serum NEFA and BHBA concentrations during week 1 were associated with the subsequent occurrence of clinical ketosis. The odds of clinical ketosis were 6.3 times greater in cows with serum NEFA ≥ 1.0mmol/L in the first week after calving. In addition, cows with BHB ≥1200μmol/L in the first week after calving, were at 4.7 times greater risk of developing clinical ketosis. In the first and second weeks after calving the serum Ca concentration was associated with subsequent culling. In addition, cows with NEFA concentration ≥ 1.0mmol/L were 3.6 times more likely to be culled within the following 2 months. The study indicated that early post-partum serum BHBA, NEFA and Ca concentrations have potential as indicators of disease and culling risk in dairy cows.
本研究旨在探讨奶牛产后血清非酯化脂肪酸（NEFA）、β-羟丁酸（BHBA）、血糖和钙（Ca）与真胃移位（DA）、临床酮病和淘汰之间的关系。从产后第 1 周到第 3 周，每周从 16 个农场的 849 头奶牛中采集样本。从奶牛分娩到泌乳第 60 天（DIM）期间对奶牛进行临床观察，在此期间有 22 例 DA、31 例临床酮病和 39 头奶牛被淘汰。BHBA 浓度升高与 DA、临床酮病和淘汰有关。产后第 1 周，血清 BHBA≥1000μmol/L 的奶牛发生 DA 的可能性是 BHBA 值较低奶牛的 13.6 倍。产后第 1 周血清 NEFA 和 BHBA 浓度与随后发生的临床酮病有关。产后第 1 周血清 NEFA≥1.0mmol/L 的奶牛发生临床酮病的可能性增加 6.3 倍。此外，产后第 1 周血清 BHBA≥1200μmol/L 的奶牛发生临床酮病的风险增加 4.7 倍。产后第 1 周到第 2 周，血清 Ca 浓度与随后的淘汰有关。此外，产后第 1 周 NEFA 浓度≥1.0mmol/L 的奶牛在接下来的 2 个月内淘汰的可能性增加 3.6 倍。该研究表明，产后早期血清 BHBA、NEFA 和 Ca 浓度可能成为奶牛疾病和淘汰风险的指标。
