果蝇免疫反应中的 NF-κB。
NF-kappaB in the immune response of Drosophila.
机构信息
Centre National de la Recherche Scientifique, Institute of Molecular and Cellular Biology, 15 rue René Descartes, 67084 Strasbourg, France.
出版信息
Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a000232. doi: 10.1101/cshperspect.a000232. Epub 2009 Oct 7.
Abstract
The nuclear factor kappaB (NF-kappaB) pathways play a major role in Drosophila host defense. Two recognition and signaling cascades control this immune response. The Toll pathway is activated by Gram-positive bacteria and by fungi, whereas the immune deficiency (Imd) pathway responds to Gram-negative bacterial infection. The basic mechanisms of recognition of these various types of microbial infections by the adult fly are now globally understood. Even though some elements are missing in the intracellular pathways, numerous proteins and interactions have been identified. In this article, we present a general picture of the immune functions of NF-kappaB in Drosophila with all the partners involved in recognition and in the signaling cascades.
摘要
核因子 kappaB（NF-κB）途径在果蝇宿主防御中起主要作用。两条识别和信号级联控制着这种免疫反应。Toll 途径被革兰氏阳性菌和真菌激活，而免疫缺陷（Imd）途径则对革兰氏阴性菌感染作出反应。成虫对这些不同类型的微生物感染的识别的基本机制现在已被全球所理解。尽管细胞内途径中缺少一些元素，但已经鉴定出许多蛋白质和相互作用。在本文中，我们展示了果蝇中 NF-κB 的免疫功能的总体情况，包括涉及识别和信号级联的所有伙伴。
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