Hollak C E, Prummel M F, Tiel-van Buul M M
Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
J Intern Med. 1991 Jun;229(6):545-8. doi: 10.1111/j.1365-2796.1991.tb00394.x.
In a patient with primary aldosteronism, in which the postural endocrine tests suggested the presence of an aldosteronoma rather than hyperplasia, bilateral adrenal tumours were found by computer tomography. Adrenal scintigraphy using 6-131I-iodomethyl-19-norcholesterol (NP59) during dexamethasone suppression showed early unilateral adrenal visualization on the left side. After removal of the left adrenal gland, which contained a 2 x 2 x 2 cm adenoma, the blood pressure and aldosterone levels returned to normal. A CT-scan, performed 1 year after the pre-operative CT-scan, showed no change in size of the right adrenal tumour, consistent with a non-functioning adenoma. In this patient, the NP59 scan adequately distinguished a non-functioning from an aldosterone-producing adrenal tumour.
在一名原发性醛固酮增多症患者中，体位性内分泌检查提示存在醛固酮瘤而非增生，计算机断层扫描发现双侧肾上腺肿瘤。地塞米松抑制期间使用6-¹³¹I-碘甲基-19-去甲胆固醇（NP59）进行的肾上腺闪烁显像显示左侧肾上腺早期单侧显影。切除含有一个2×2×2 cm腺瘤的左侧肾上腺后，血压和醛固酮水平恢复正常。术前CT扫描1年后进行的CT扫描显示右侧肾上腺肿瘤大小无变化，符合无功能腺瘤。在该患者中，NP59扫描充分区分了无功能肾上腺肿瘤和产生醛固酮的肾上腺肿瘤。
