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本文引用的文献

1
The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.抑制丙酮酸脱氢酶激酶可改善两种右心室肥厚模型中心功能和电重构障碍：使冬眠右心室复苏。
J Mol Med (Berl). 2010 Jan;88(1):47-60. doi: 10.1007/s00109-009-0524-6. Epub 2009 Dec 1.
2
Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension.用于治疗肺动脉高压的5型磷酸二酯酶抑制剂。
N Engl J Med. 2009 Nov 5;361(19):1864-71. doi: 10.1056/NEJMct0904473.
3
Dichloroacetate treatment partially regresses established pulmonary hypertension in mice with SM22alpha-targeted overexpression of the serotonin transporter.SM22α 靶向过表达 5-羟色胺转运体的小鼠应用二氯乙酸治疗部分逆转已建立的肺动脉高压。
FASEB J. 2009 Dec;23(12):4135-47. doi: 10.1096/fj.09-131664. Epub 2009 Aug 13.
4
Spotlight on sapropterin in primary hyperphenylalaninemia.原发性高苯丙氨酸血症中四氢生物蝶呤的聚焦
BioDrugs. 2009;23(3):201-2. doi: 10.2165/00063030-200923030-00007.
5
Updated clinical classification of pulmonary hypertension.肺动脉高压的更新临床分类。
J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S43-S54. doi: 10.1016/j.jacc.2009.04.012.
6
Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway.白细胞介素-6通过一条新的信号转导和转录激活因子3-微小RNA簇17/92途径调节Ⅱ型骨形态发生蛋白受体的表达。
Circ Res. 2009 May 22;104(10):1184-91. doi: 10.1161/CIRCRESAHA.109.197491. Epub 2009 Apr 23.
7
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension.TRPC6基因启动子区一个与特发性肺动脉高压相关的功能性单核苷酸多态性。
Circulation. 2009 May 5;119(17):2313-22. doi: 10.1161/CIRCULATIONAHA.108.782458. Epub 2009 Apr 20.
8
Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.利奥西呱（BAY 63-2521）的发现：一种用于治疗肺动脉高压的强效口服可溶性鸟苷酸环化酶刺激剂。
ChemMedChem. 2009 May;4(5):853-65. doi: 10.1002/cmdc.200900014.
9
Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells.血清素诱导肺动脉平滑肌细胞中Rho/ROCK依赖性的Smads 1/5/8激活。
FASEB J. 2009 Jul;23(7):2299-306. doi: 10.1096/fj.08-127910. Epub 2009 Feb 25.
10
Association of the metabolic syndrome with pulmonary venous hypertension.代谢综合征与肺静脉高压的关联。
Chest. 2009 Jul;136(1):31-36. doi: 10.1378/chest.08-2008. Epub 2009 Feb 2.

Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies.

作者信息

Archer Stephen L, Weir E Kenneth, Wilkins Martin R

机构信息

University of Chicago, IL 60637, USA.

出版信息

Circulation. 2010 May 11;121(18):2045-66. doi: 10.1161/CIRCULATIONAHA.108.847707.

DOI:10.1161/CIRCULATIONAHA.108.847707
PMID:20458021
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2869481/
Abstract
摘要