Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, Netherlands.
Am J Cardiol. 2012 Sep 15;110(6 Suppl):39S-48S. doi: 10.1016/j.amjcard.2012.06.015.
In recent years, increased understanding of cardiovascular system dynamics has led to the development of mathematical models of the heart and circulation. Models that enable realistic simulation of ventricular mechanics and interactions under a range of conditions have the potential to provide an ideal method with which to investigate the effects of pulmonary arterial hypertension and its treatment on cardiac mechanics and hemodynamics. Such mathematical models have the potential to contribute to a personalized, patient-specific treatment approach and allow more objective diagnostic decision-making, patient monitoring, and assessment of treatment outcome. This review discusses the development of mathematical models of the heart and circulation, with particular reference to the closed-loop CircAdapt model, and how the model performs under both normal and pathophysiological (pulmonary hypertensive) conditions.
近年来，人们对心血管系统动力学的认识不断加深，这促使人们开发出了心脏和循环的数学模型。这些模型能够在各种条件下对心室力学和相互作用进行逼真的模拟，有望为研究肺动脉高压及其治疗对心脏力学和血液动力学的影响提供一种理想的方法。这种数学模型有可能有助于实现个性化、针对患者个体的治疗方法，并能够更客观地进行诊断决策、患者监测和治疗效果评估。本文讨论了心脏和循环的数学模型的开发，特别提到了闭环 CircAdapt 模型，以及该模型在正常和病理生理（肺动脉高压）条件下的表现。
