Kaneda N, Pezzuto J M, Soejarto D D, Kinghorn A D, Farnsworth N R, Santisuk T, Tuchinda P, Udchachon J, Reutrakul V
College of Pharmacy, University of Illinois, Chicago 60612.
J Nat Prod. 1991 Jan-Feb;54(1):196-206. doi: 10.1021/np50073a019.
From a cytotoxic Et2O-soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1-7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1-12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on 1H-1H COSY, 1H-13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines.
从赛葵根的细胞毒性乙醚可溶提取物中分离出12种新黄酮类化合物，包括7种黄烷（1-7）、3种黄酮（8、10和12）以及2种双黄酮（9和11）。通过光谱数据解析确定了化合物1-12的结构，这些成分的核磁共振归属基于1H-1H COSY、1H-13C HETCOR和选择性INEPT实验。这是首次报道7,8-二-O-取代黄烷、双黄酮和黄酮的存在。大多数分离物在针对培养的P-388细胞进行测试时表现出细胞毒性活性，其中黄烷比黄酮更具活性。此外，当用多种人类癌细胞系进行评估时，某些这些结构相关的黄酮类化合物表现出一定的选择性活性。
