Autonomic Laboratory, Neurological Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106-5040, USA.
Clin Auton Res. 2010 Aug;20(4):223-7. doi: 10.1007/s10286-010-0070-x. Epub 2010 May 11.
We determine the comorbid conditions associated with syncope in women. In addition, we hypothesize a higher proportion of autonomic comorbid conditions during the female reproductive age.
We identified a cohort of patients admitted to US hospitals with the principal diagnosis of syncope. We compare patient demographics stratified by gender as well as syncope associated comorbidities. We compared these comorbidities in female of reproductive age (15-45) to men as control.
From a total sample of 305,932, females constituted 56.7% (n = 173,434). Females were slightly older (mean age 70.9 +/- 17.9 vs. 66.7 +/- 17.3; P < 0.0001); with similar racial distribution (white 57.8 vs. 57.5%), and similar length of hospital stay (mean 2.66 +/- 2.63 vs. 2.68 +/- 2.72 days; P > 0.05). Females had higher proportion of migraine (1.65 vs. 1.29%; odds ratio 'OR' 1.29; 95% confidence interval 'CI' 1.21, 1.36); chronic fatigue syndrome (1.73 vs. 1.3%; OR 1.32; 95% CI 1.25, 1.4); gastroparesis (0.2 vs. 0.12%; OR 1.64; 95% CI 1.35, 1.98); interstitial cystitis (0.07 vs. 0.01%; OR 7.44; 95% CI 4.10, 13.5); and postural tachycardia syndrome (0.49 vs. 0.44%; OR 1.1; 95% CI 1.001, 1.23). Orthostatic hypotension was not different between the groups (P = 0.24). When the sample was stratified by age category, the odds ratio for gastroparesis, orthostatic hypotension, and postural tachycardia syndrome was increased (P < 0.05).
A higher proportion of autonomic dysfunction was present in women compared to men. In addition, these comorbid autonomic conditions were especially prominent during the female reproductive age.
我们确定与女性晕厥相关的合并症。此外，我们假设女性生殖期自主合并症的比例更高。
我们确定了一个因晕厥主诊断而入住美国医院的患者队列。我们按性别对患者人口统计学进行分层，并比较与晕厥相关的合并症。我们将女性生殖年龄（15-45 岁）的这些合并症与男性进行比较作为对照组。
在总共 305932 名患者中，女性占 56.7%（n=173434）。女性年龄稍大（平均年龄 70.9±17.9 岁比 66.7±17.3 岁；P<0.0001）；种族分布相似（白人 57.8%比 57.5%），住院时间相似（平均 2.66±2.63 天比 2.68±2.72 天；P>0.05）。女性偏头痛的比例更高（1.65%比 1.29%；优势比'OR'1.29；95%置信区间'CI'1.21，1.36）；慢性疲劳综合征（1.73%比 1.3%；OR 1.32；95% CI 1.25，1.4）；胃轻瘫（0.2%比 0.12%；OR 1.64；95% CI 1.35，1.98）；间质性膀胱炎（0.07%比 0.01%；OR 7.44；95% CI 4.10，13.5）；体位性心动过速综合征（0.49%比 0.44%；OR 1.1；95% CI 1.001，1.23）。两组之间直立性低血压无差异（P=0.24）。当按年龄分类分层样本时，胃轻瘫、直立性低血压和体位性心动过速综合征的比值比增加（P<0.05）。
与男性相比，女性自主功能障碍的比例更高。此外，这些自主合并症在女性生殖期尤为突出。
