van Campen C Linda M C, Rowe Peter C, Visser Frans C
Stichting Cardiozorg, Hoofddorp, Netherlands.
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Front Pediatr. 2018 Nov 15;6:352. doi: 10.3389/fped.2018.00352. eCollection 2018.
Conflicting data have been published on the reduction of circulating blood volume in adults with Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The aim of the present study was to compare blood volumes based on the presence or absence of orthostatic symptoms. Twenty consecutive adults with ME/CFS participated in the study. All underwent dual isotope blood volume measurement and were evaluated for a clinical suspicion of orthostatic intolerance (OI). The mean age was 34 (10) years, and median duration of disease was 7.5 (6-10) years. The mean (SD) absolute blood volume was 59 (8) ml/kg, a value -11 (7) ml/kg below the reference blood volume. Of the 12 patients, 4 had no OI and 8 had a clinical suspicion of OI. In 8 patients with OI, absolute blood volumes were significantly lower than for the 4 without OI (56 [2] vs. 66 [5]; < 0.05) as were the differences between the measured and the reference blood volume (-14 [2]; vs. -4 [3]; < 0.02). Adults with ME/CFS had a significantly lower blood volume if they had a clinical suspicion of OI compared to those without a clinical suspicion of OI, as well as a significantly lower blood volume compared to the expected value. The data suggest that accounting for symptoms of OI could enhance the detection of the subset with reduced blood volume.
关于肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）成人患者循环血容量减少的问题，已发表了相互矛盾的数据。本研究的目的是根据是否存在直立性症状比较血容量。20名连续的ME/CFS成人患者参与了该研究。所有人均接受了双同位素血容量测量，并对直立不耐受（OI）的临床怀疑进行了评估。平均年龄为34（10）岁，疾病持续时间中位数为7.5（6 - 10）年。平均（标准差）绝对血容量为59（8）ml/kg，比参考血容量低 - 11（7）ml/kg。在这12名患者中，4人无OI，8人有OI临床怀疑。在8名有OI的患者中，绝对血容量显著低于4名无OI的患者（56 [2] vs. 66 [5]；P < 0.05），测量血容量与参考血容量之间的差异也是如此（-14 [2]；vs. -4 [3]；P < 0.02）。与无OI临床怀疑的ME/CFS成人患者相比，有OI临床怀疑的患者血容量显著更低，且与预期值相比血容量也显著更低。数据表明，考虑OI症状可能会增强对血容量减少亚组的检测。
