van Tilburg A J, de Rooij F W, van den Berg J W, Kooij P P, van Blankenstein M
Department of Internal Medicine II, University Hospital Dijkzigt, Rotterdam, The Netherlands.
J Nucl Med. 1991 Jun;32(6):1219-24.
The recommended reference values for the selenium-75-homocholic acid taurine (75SeHCAT) test, used in the analysis of chronic diarrhea, were evaluated in 211 patients by comparing simultaneous measurements of 3 alpha-hydroxy bile acids and 75Se activity in daily collected stools. An initial evaluation in 11 patients showed that the fecal collection method, which allows inspection and additional analysis of stools, was equivalent to the abdominal retention method. Selenium-75-HCAT whole-body retention half-life (WBR50) was greater than 2.8 days in less than 10% of the patients with bile acid malabsorption and less than 1.7 days in less than 10% of the normals. We recommend that a 75SeHCAT WBR50 less than 1.7 days is abnormal, a WBR50 greater than 2.8 days is normal, and a WBR50 in the range 1.7-2.8 days is equivocal, which was the case in 48% (94/195) of the patients in this study.
通过比较每日收集粪便中3α-羟基胆汁酸和75硒活性的同步测量结果，对211例患者进行了用于慢性腹泻分析的硒-75-高胆酸牛磺酸（75SeHCAT）试验的推荐参考值评估。对11例患者的初步评估表明，允许对粪便进行检查和额外分析的粪便收集方法与腹部保留法相当。在胆汁酸吸收不良患者中，不到10%的患者75硒-高胆酸牛磺酸全身保留半衰期（WBR50）大于2.8天，在正常人群中，不到10%的人WBR50小于1.7天。我们建议，75SeHCAT WBR50小于1.7天为异常，WBR50大于2.8天为正常，WBR50在1.7 - 2.8天之间为可疑，本研究中48%（94/195）的患者属于这种情况。
