• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

飞行时间双光子发射计算机断层扫描。

Time of flight dual photon emission computed tomography.

机构信息

Medical Physics Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu, Taiwan.

出版信息

Sci Rep. 2020 Nov 11;10(1):19514. doi: 10.1038/s41598-020-76526-z.

DOI:10.1038/s41598-020-76526-z
PMID:33177616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7659351/
Abstract

Time-of-flight dual photon emission computed tomography (TOF-DuPECT) is an imaging system that can obtain radionuclide distributions using time information recorded from two cascade-decay photons. The potential decay locations in the image space, a hyperbolic response curve, can be determined via time-difference-of-arrival (TDOA) estimations from two instantaneous coincidence photons. In this feasibility study, Monte Carlo simulations were performed to generate list-mode coincidence data. A full-ring positron emission tomography-like detection system geometry was built in the simulation environment. A contrast phantom and a Jaszczak-like phantom filled with Selenium-75 (Se-75) were used to evaluate the image quality. A TOF-DuPECT system with varying coincidence time resolution (CTR) was then evaluated. We used the stochastic origin ensemble (SOE) algorithm to reconstruct images from the recorded list-mode data. The results indicate that the SOE method can be successfully employed for the TOF-DuPECT system and can achieve acceptable image quality when the CTR is less than 100 ps. Therefore, the TOF-DuPECT imaging system is feasible. With the improvement of the detector with time, future implementations and applications of TOF-DuPECT are promising. Further quantitative imaging techniques such as attenuation and scatter corrections for the TOF-DuPECT system will be developed in future.

摘要

飞行时间双光子发射计算机断层成像（TOF-DuPECT）是一种成像系统，它可以利用从两个级联衰变光子记录的时间信息来获得放射性核素分布。通过两个瞬时符合光子的到达时间差（TDOA）估计，可以确定图像空间中的潜在衰变位置，即双曲线响应曲线。在这项可行性研究中，进行了蒙特卡罗模拟以生成列表模式符合数据。在模拟环境中构建了全环正电子发射断层扫描样检测系统几何形状。使用对比度体模和充满硒-75（Se-75）的 Jaszczak 样体模来评估图像质量。然后评估了具有不同符合时间分辨率（CTR）的 TOF-DuPECT 系统。我们使用随机起源集合（SOE）算法从记录的列表模式数据中重建图像。结果表明，SOE 方法可成功应用于 TOF-DuPECT 系统，并且当 CTR 小于 100 ps 时可以实现可接受的图像质量。因此，TOF-DuPECT 成像系统是可行的。随着探测器时间的提高，TOF-DuPECT 的未来实现和应用前景广阔。未来将开发用于 TOF-DuPECT 系统的衰减和散射校正等定量成像技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/b7bba5580c28/41598_2020_76526_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/9adde8944f01/41598_2020_76526_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/82b3784aff64/41598_2020_76526_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/ba4f94ecb89d/41598_2020_76526_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/36d34a621f83/41598_2020_76526_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/b840c5b3f8bd/41598_2020_76526_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/96ab832a7cae/41598_2020_76526_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/9f55b5628352/41598_2020_76526_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/b9e2f757df4f/41598_2020_76526_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/b65d6847af69/41598_2020_76526_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/b7bba5580c28/41598_2020_76526_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/9adde8944f01/41598_2020_76526_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/82b3784aff64/41598_2020_76526_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/ba4f94ecb89d/41598_2020_76526_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/36d34a621f83/41598_2020_76526_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/b840c5b3f8bd/41598_2020_76526_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/96ab832a7cae/41598_2020_76526_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/9f55b5628352/41598_2020_76526_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/b9e2f757df4f/41598_2020_76526_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/b65d6847af69/41598_2020_76526_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f14/7659351/b7bba5580c28/41598_2020_76526_Fig10_HTML.jpg

相似文献

1
Time of flight dual photon emission computed tomography.飞行时间双光子发射计算机断层扫描。
Sci Rep. 2020 Nov 11;10(1):19514. doi: 10.1038/s41598-020-76526-z.
2
Feasibility study of a point-of-care positron emission tomography system with interactive imaging capability.交互式成像性能的即时检测正电子发射断层成像系统的可行性研究。
Med Phys. 2019 Apr;46(4):1798-1813. doi: 10.1002/mp.13397. Epub 2019 Feb 14.
3
High-resolution time-of-flight PET detector with 100 ps coincidence time resolution using a side-coupled phoswich configuration.采用边耦合型多晶硅光电倍增管技术的时间分辨率为 100ps 的高分辨率飞行时间正电子发射断层成像探测器。
Phys Med Biol. 2021 Jun 9;66(12). doi: 10.1088/1361-6560/ac01b5.
4
Compton scatter tomography in TOF-PET.TOF-PET中的康普顿散射断层扫描
Phys Med Biol. 2017 Sep 12;62(19):7641-7658. doi: 10.1088/1361-6560/aa82ab.
5
Scatter and crosstalk corrections for (99m)Tc/(123)I dual-radionuclide imaging using a CZT SPECT system with pinhole collimators.使用带有针孔准直器的CZT单光子发射计算机断层显像（SPECT）系统对（99m）锝/（123）碘双放射性核素成像进行散射和串扰校正
Med Phys. 2015 Dec;42(12):6895-911. doi: 10.1118/1.4934830.
6
Monte Carlo simulation of PET and SPECT imaging of 90Y.90Y正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）成像的蒙特卡罗模拟
Med Phys. 2015 Apr;42(4):1926-35. doi: 10.1118/1.4915545.
7
Effects of system geometry and other physical factors on photon sensitivity of high-resolution positron emission tomography.系统几何结构及其他物理因素对高分辨率正电子发射断层扫描光子灵敏度的影响。
Phys Med Biol. 2007 Jul 7;52(13):3753-72. doi: 10.1088/0031-9155/52/13/007. Epub 2007 May 29.
8
Study of optical reflectors for a 100ps coincidence time resolution TOF-PET detector design.用于 100ps 符合时间分辨率 TOF-PET 探测器设计的光学反射器研究。
Biomed Phys Eng Express. 2021 Sep 15;7(6). doi: 10.1088/2057-1976/ac240e.
9
Simulation of ionization charge carrier cascade time and density for a new radiation detection method based on modulation of optical properties.基于光学性质调制的新型辐射探测方法中电离电荷载流子级联时间和密度的模拟
Med Phys. 2024 Feb;51(2):1383-1395. doi: 10.1002/mp.16855. Epub 2023 Dec 8.
10
Experimental time resolution limits of modern SiPMs and TOF-PET detectors exploring different scintillators and Cherenkov emission.现代硅光电倍增管和飞行时间正电子发射断层扫描探测器探索不同闪烁体和切伦科夫发射的实验时间分辨率限制。
Phys Med Biol. 2020 Jan 17;65(2):025001. doi: 10.1088/1361-6560/ab63b4.

本文引用的文献

1
Simulation study to improve the performance of a whole-body PbF Cherenkov TOF-PET scanner.全身 PbF 切伦科夫 TOF-PET 扫描仪性能提升的仿真研究。
Phys Med Biol. 2020 Mar 6;65(5):055013. doi: 10.1088/1361-6560/ab6f97.
2
A noise smoothing origin ensemble algorithm based on local filtering.基于局部滤波的噪声平滑起源集总算法。
Phys Med Biol. 2019 Aug 7;64(15):155020. doi: 10.1088/1361-6560/ab280c.
3
Feasibility study of the positronium imaging with the J-PET tomograph.正电子成像的可行性研究与 J-PET 断层扫描仪。
Phys Med Biol. 2019 Mar 7;64(5):055017. doi: 10.1088/1361-6560/aafe20.
4
Performance Characteristics of the Digital Biograph Vision PET/CT System.Digital Biograph Vision PET/CT 系统的性能特点。
J Nucl Med. 2019 Jul;60(7):1031-1036. doi: 10.2967/jnumed.118.215418. Epub 2019 Jan 10.
5
Performance Evaluation of the Vereos PET/CT System According to the NEMA NU2-2012 Standard.根据 NEMA NU2-2012 标准对 Vereos PET/CT 系统进行性能评估。
J Nucl Med. 2019 Apr;60(4):561-567. doi: 10.2967/jnumed.118.215541. Epub 2018 Oct 25.
6
Evaluation of a clinical TOF-PET detector design that achieves ⩽100 ps coincidence time resolution.评估一种临床 TOF-PET 探测器设计，该设计可实现 ⩽100 ps 的符合时间分辨率。
Phys Med Biol. 2018 Jun 7;63(11):115011. doi: 10.1088/1361-6560/aac504.
7
Studies of a Next-Generation Silicon-Photomultiplier-Based Time-of-Flight PET/CT System.基于下一代硅光电倍增管的飞行时间PET/CT系统的研究。
J Nucl Med. 2017 Sep;58(9):1511-1518. doi: 10.2967/jnumed.117.189514. Epub 2017 Apr 27.
8
A method to assess image quality for Low-dose PET: analysis of SNR, CNR, bias and image noise.一种评估低剂量正电子发射断层扫描（PET）图像质量的方法：信噪比（SNR）、对比度噪声比（CNR）、偏差及图像噪声分析
Cancer Imaging. 2016 Aug 26;16(1):26. doi: 10.1186/s40644-016-0086-0.
9
Resolution recovery for Compton camera using origin ensemble algorithm.基于原始总体算法的康普顿相机分辨率恢复
Med Phys. 2016 Aug;43(8):4866. doi: 10.1118/1.4959551.
10
NEMA NU 2-2012 performance studies for the SiPM-based ToF-PET component of the GE SIGNA PET/MR system.通用电气Signa PET/MR系统基于硅光电倍增管的飞行时间正电子发射断层显像组件的NEMA NU 2-2012性能研究。
Med Phys. 2016 May;43(5):2334. doi: 10.1118/1.4945416.