Founds Sandra A, Catov Janet M, Gallaher Marcia J, Harger Gail F, Markovic Nina, Roberts James M
School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Hypertens Pregnancy. 2011;30(1):1-10. doi: 10.3109/10641950903322907. Epub 2010 May 12.
To examine whether high insulin resistance versus high inflammation identifies subtypes of preeclampsia.
A cytokine panel, glucose and insulin were measured in 37 preeclampsia plasma samples. Wilcoxon rank sum assessed median concentration of HOMA(IR) by pro-inflammatory:anti-inflammatory ratio. Regression stratifying by BMI and preterm birth was conducted.
There was no difference in median HOMA(IR) by the pro-inflammatory:anti-inflammatory ratio (p = 0.16). No subsets scatterplot clusters emerged. A positive correlation between HOMAlog and the ratio was significant (p = 0.04).
No dichotomous subsets of preeclampsia by inflammation versus insulin resistance were detected. Contrary to our hypothesis, insulin resistance was higher as inflammation increased in preeclampsia.
研究高胰岛素抵抗与高炎症反应是否可鉴别子痫前期的亚型。
检测37份子痫前期血浆样本中的细胞因子组、葡萄糖和胰岛素水平。采用Wilcoxon秩和检验按促炎：抗炎比例评估HOMA（IR）的中位数浓度。进行了按BMI和早产分层的回归分析。
按促炎：抗炎比例计算，HOMA（IR）的中位数无差异（p = 0.16）。未出现子集散点图聚类。HOMAlog与该比例之间存在显著正相关（p = 0.04）。
未检测到按炎症反应与胰岛素抵抗划分的子痫前期二分法子集。与我们的假设相反，子痫前期中炎症反应增加时胰岛素抵抗更高。
