Pulmonary Critical Care Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Proc Am Thorac Soc. 2010 May;7(3):204-9. doi: 10.1513/pats.200906-050AL.
Invasive aspergillosis is a common and devastating complication in severely immune-suppressed individuals with hematologic malignancies and in hematopoietic stem cell transplant recipients. With the increase use of immunosuppressive therapies, better intensive care, and prolonged patient survival, we are experiencing a surge in the incidence of invasive aspergillosis in our critically ill patients without malignancy. In this article we discuss the epidemiology, risk factors, and clinical spectrum of invasive aspergillosis in critically ill patients without malignancy. Diagnostic methods and recommended treatments are also presented. The emphasis is placed on early diagnosis and use of new and sensitive diagnostic tools.
侵袭性曲霉菌病是血液恶性肿瘤患者和造血干细胞移植受者等严重免疫抑制个体中常见且具破坏性的并发症。随着免疫抑制治疗的广泛应用、重症监护的改善和患者生存期的延长，我们在非恶性重症患者中也经历了侵袭性曲霉菌病发病率的急剧上升。本文讨论了非恶性重症患者侵袭性曲霉菌病的流行病学、危险因素和临床特征。还介绍了诊断方法和推荐的治疗方法。重点是早期诊断和使用新的、敏感的诊断工具。
