Department of Pathology, University of Bologna School of Medicine, Bologna, Italy.
Am J Surg Pathol. 2010 Jun;34(6):868-72. doi: 10.1097/PAS.0b013e3181dbee07.
A cohort of 1039 consecutive cases of thyroid carcinoma treated at a single institution and followed for an average of 11.9 years or until death included 102 encapsulated well-differentiated follicular-patterned tumors that had been diagnosed as carcinoma because of complete capsular invasion and/or papillary carcinoma-type nuclei. None of these cases were among the 67 patients from the cohort who died as a result of their thyroid carcinoma. The results of this study and a critical review of the pertinent literature indicate that tumors with these features are associated with an extremely favorable outcome and that they do not play a significant role in the fatality rate of thyroid carcinoma.
在一家机构治疗并随访平均 11.9 年或直至死亡的 1039 例连续甲状腺癌病例中，包括 102 例包膜完整、分化良好的滤泡模式肿瘤，这些肿瘤因完全包膜浸润和/或乳头状癌样核而被诊断为癌。这些病例均不属于该队列中因甲状腺癌而死亡的 67 名患者之一。本研究的结果和对相关文献的批判性回顾表明，具有这些特征的肿瘤与极好的预后相关，它们在甲状腺癌死亡率中没有起到重要作用。
