[Expression of BDNF mRNA in nasal mucosa with allergic rhinitis rat model].
作者信息
Tao Feng, Zhang Fengbing, Huang Zhichun, Sun Baobin, Feng Xu
机构信息
Department of Otorhinolaryngology, Zhongda Hospital, Southeast University, Nanjing, 210009, China.
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Mar;24(5):224-6.
OBJECTIVE
To evaluate the role of brain-derived neurotrophic factor (BDNF) in allergic rhinitis of rat.
METHOD
Thirty SD rats free of disease were randomly divided into two groups. A model of allergic rhinitis rat was established by using ovalbumin intraperitoneal immunization and intranasal antigen challenge. The nasal mucosa from 18 out of 20 AR models as well as 10 normal controls were studied for expression of BDNF mRNA by reverse transcription-polymerase chain reaction (RT-PCR).
RESULT
BDNF/beta-actin ratio in AR models was significantly higher than control (0.49+/-0.07 vs 0.28+/-0.01, P<0.05).
CONCLUSION
BDNF played an important role in the development of allergic rhinitis of rat.
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