2-杂环 N-甲基亚氨基二乙酸硼酸酯的一般合成方法。
General method for synthesis of 2-heterocyclic N-methyliminodiacetic acid boronates.
机构信息
Howard Hughes Medical Institute, Roger Adams Lab, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
出版信息
Org Lett. 2010 May 21;12(10):2314-7. doi: 10.1021/ol100671v.
Abstract
A wide range of 2-pyridyl and other difficult-to-access heterocyclic N-methyliminodiacetic acid boronates can be readily prepared from the corresponding bromides via a new method involving direct transligation of 2-heterocyclic trialkoxyborate salts with N-methyliminodiacetic acid (MIDA) at elevated temperatures.
摘要
一系列广泛的 2-吡啶基和其他难以获得的杂环 N-甲基亚氨基二乙酸硼酸酯可通过一种新方法从相应的溴化物中容易地制备，该方法涉及在高温下直接与 N-甲基亚氨基二乙酸（MIDA）进行 2-杂环三烷氧基硼酸盐盐的反式亲核取代反应。
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