Laboratory of Biology, University of Athens, School of Medicine and Biomedical Research Foundation of the Academy of Athens, Greece.
2nd Gastroenterology Department, Evangelismos Hospital, Athens, Greece.
Gut Pathog. 2010 May 13;2(1):3. doi: 10.1186/1757-4749-2-3.
Irritable Bowel Syndrome (IBS) represents a functional disorder of gastrointestinal tract without the presence of an anatomic defect, in which abdominal pain is relieved with defecation and is associated with altered bowel habits.IBS includes a wide range of symptoms while its pathophysiology is very complicated. Recent studies indicate that the most important mechanisms include visceral sensitivity, abnormal gut motility and autonomous nervous system dysfunction. The interactions between these three mechanisms make bowel's function susceptible to many exogenous and endogenous factors like gastrointestinal flora, feeding and psychosocial factors. Recent data indicate that according to the above mechanisms, the influence of genetic factors and polymorphisms of human DNA in the development of IBS is equally important.
肠易激综合征（IBS）代表一种没有解剖缺陷的胃肠道功能障碍，其腹痛在排便后缓解，并伴有排便习惯改变。IBS 包括广泛的症状，其病理生理学非常复杂。最近的研究表明，最重要的机制包括内脏敏感性、肠道运动异常和自主神经系统功能障碍。这三种机制的相互作用使肠道功能容易受到许多内外源性因素的影响，如胃肠道菌群、饮食和心理社会因素。最近的数据表明，根据上述机制，遗传因素和人类 DNA 多态性在 IBS 发展中的影响同样重要。
