National Trauma Research Institute & Monash University, Level 6, 99 Commercial Road, Melbourne, VIC 3004, Australia.
Injury. 2010 Jul;41 Suppl 1:S3-6. doi: 10.1016/j.injury.2010.04.016. Epub 2010 May 13.
Clinicians and researchers seek answers to clinical research questions, primarily by accessing the results of clinical research studies. This paper moves the focus of research enquiry from getting answers to developing good clinical research questions. Using worked examples, the steps involved in refining questions drawn from various sources to create 'answerable' clinical research questions using the 'PICO' principle are described. Issues to consider in prioritising clinical research questions are also identified. Theoretical and practical considerations involved in choosing the right study design for a clinical research question are then discussed using the worked examples. These include:
临床医生和研究人员通过查阅临床研究结果来寻求临床研究问题的答案。本文将研究重点从寻找答案转移到提出好的临床研究问题上。本文通过实例，描述了如何使用“PICO”原则，从不同来源提炼问题，并将其细化为“可回答”的临床研究问题。本文还确定了在优先考虑临床研究问题时需要考虑的问题。然后，本文使用实例讨论了为临床研究问题选择正确研究设计时涉及的理论和实践考虑因素。这些因素包括：
