Department of Neuroscience, University of Palermo, Buenos Aires, Argentina.
J Affect Disord. 2010 Dec;127(1-3):38-42. doi: 10.1016/j.jad.2010.04.015. Epub 2010 May 13.
The aim of this study was to investigate the role of hyperthymic temperament in suicidal ideation between a sample of patients with affective disorders (unipolar and bipolar).
We investigated affective disorders outpatients (unipolar, bipolar I, II and NOS) treated in eleven participating centres during at least a six-month period. DSM-IV diagnosis was made by psychiatrists experienced in mood disorders, using the corresponding modules of the Mini International Neuropsychiatric Interview (MINI). In addition, bipolar NOS diagnoses were extended by guidelines for bipolar spectrum symptoms as proposed by Akiskal and Pinto in 1999. Thereby we also identified NOS III (switch by antidepressants) and NOS IV (hyperthymic temperament) bipolar subtypes. All patients completed the Beck Depression Inventory (BDI). We screened a total sample of 411 patients (69% bipolar), 352 completed all the clinical scales without missing any item.
No statistical significant difference in suicidal ideation (measure by BDI item 9 responses) was found between bipolar and unipolar patients (4.5% vs. 9.1%, respectively). On the group of bipolar patients, suicidal ideation was slightly more frequent among bipolar NOS compared with bipolar I and II (p value 0.094 and 0.086, respectively), interestingly we found a statistical significant less common suicidal ideation among bipolar subtype IV (with hyperthymic temperament) compared with bipolar NOS patients (p value 0.048).
Our results indicate that those subjects with hyperthymic temperament displayed less suicidal ideation. This finding supports the hypothesis that this particular affective temperament could be a protective factor against suicide among affective patients.
The original objective of the national study was the cross validation between MDQ and BSDS in patients with affective disorders in our country. This report arises from a secondary analysis of the original data.
本研究旨在探讨躁狂气质在情感障碍患者（单相和双相）自杀意念中的作用。
我们调查了在 11 个参与中心接受治疗的至少六个月的情感障碍门诊患者（单相、双相 I、II 和 NOS）。DSM-IV 诊断由经验丰富的心境障碍精神科医生使用相应的 Mini 国际神经精神访谈（MINI）模块进行。此外，双相 NOS 诊断还扩展了 Akiskal 和 Pinto 于 1999 年提出的双相谱症状指南。由此，我们还确定了 NOS III（抗抑郁药转换）和 NOS IV（躁狂气质）双相亚型。所有患者均完成贝克抑郁量表（BDI）。我们对总共 411 名患者（69%为双相）进行了筛查，其中 352 名患者完成了所有临床量表，没有遗漏任何项目。
在自杀意念（BDI 项目 9 反应衡量）方面，双相和单相患者之间无统计学显著差异（分别为 4.5%和 9.1%）。在双相患者组中，双相 NOS 患者的自杀意念略高于双相 I 和 II 患者（p 值分别为 0.094 和 0.086），有趣的是，我们发现双相 IV 亚型（躁狂气质）患者的自杀意念明显较不常见，与双相 NOS 患者相比（p 值为 0.048）。
我们的结果表明，那些具有躁狂气质的患者自杀意念较少。这一发现支持了这样一种假设，即这种特殊的情感气质可能是情感障碍患者自杀的保护因素。
该全国性研究的最初目的是在我们国家的情感障碍患者中验证 MDQ 和 BSDS 之间的交叉验证。本报告是对原始数据的二次分析。
