Mori Y, Nishihara M, Tanaka T, Shimizu T, Yamaguchi M, Takeuchi Y, Hoshino K
Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, Japan.
Neuroendocrinology. 1991 Apr;53(4):392-5. doi: 10.1159/000125746.
A characteristic increase in multiple-unit activity (MUA volley) synchronized with the pulsatile secretion of luteinizing hormone (LH) by the pituitary gland was recorded from electrodes chronically implanted in the medial basal hypothalamus of ovariectomized goats. The MUA volley always preceded the LH pulse, and the temporal correlation was consistent even when the pulse frequency was altered with an anesthetic or exogenous steroids. The electrophysiological manifestation of the hypothalamic 'pulse generator' governing the secretion of gonadotropin-releasing hormone was thus demonstrated in the ruminant.
从长期植入去卵巢山羊内侧基底部下丘脑的电极记录到，多单位活动（MUA群峰电位）出现特征性增加，且与垂体促黄体生成素（LH）的脉冲式分泌同步。MUA群峰电位总是先于LH脉冲出现，即使在使用麻醉剂或外源性类固醇改变脉冲频率时，时间相关性依然一致。由此在反刍动物中证实了下丘脑“脉冲发生器”控制促性腺激素释放激素分泌的电生理表现。
