Uenoyama Yoshihisa, Pheng Vutha, Tsukamura Hiroko, Maeda Kei-Ichiro
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
J Reprod Dev. 2016 Dec 20;62(6):537-545. doi: 10.1262/jrd.2016-083. Epub 2016 Jul 29.
Kisspeptin, encoded by KISS1/Kiss1 gene, is now considered a master regulator of reproductive functions in mammals owing to its involvement in the direct activation of gonadotropin-releasing hormone (GnRH) neurons after binding to its cognate receptor, GPR54. Ever since the discovery of kisspeptin, intensive studies on hypothalamic expression of KISS1/Kiss1 and on physiological roles of hypothalamic kisspeptin neurons have provided clues as to how the brain controls sexual maturation at the onset of puberty and subsequent reproductive performance in mammals. Additionally, emerging evidence indicates the potential involvement of extra-hypothalamic kisspeptin in reproductive functions. Here, we summarize data regarding kisspeptin inside and outside the hypothalamus and revisit the physiological roles of central and peripheral kisspeptins in the reproductive functions of mammals.
由KISS1/Kiss1基因编码的亲吻素，由于其在与同源受体GPR54结合后参与促性腺激素释放激素（GnRH）神经元的直接激活，目前被认为是哺乳动物生殖功能的主要调节因子。自亲吻素被发现以来，对KISS1/Kiss1在下丘脑的表达以及下丘脑亲吻素神经元的生理作用进行的深入研究，为大脑如何控制哺乳动物青春期开始时的性成熟及随后的生殖性能提供了线索。此外，新出现的证据表明，下丘脑外的亲吻素可能参与生殖功能。在此，我们总结了有关下丘脑内外亲吻素的数据，并重新审视中枢和外周亲吻素在哺乳动物生殖功能中的生理作用。
