Redolat R, Brain P F, Simón V M
Area de Psicobiología, Facultad de Psicología, Universitat de València, Spain.
Neuropharmacology. 1991 Jan;30(1):41-6. doi: 10.1016/0028-3908(91)90040-i.
The atypical neuroleptic, sulpiride is a selective D2 antagonist, having a preferential action on mesolimbic regions. The effects of acute and chronic treatment with sulpiride on aggressive behaviour in male mice were studied using an ethologically based analysis. It was hypothesized that sulpiride would diminish "threat" and "attack" but would not produce marked "immobility", because of the mesolimbic effect referred to above. Isolated albino male mice (experimental animals) were confronted by "standard opponents". Acutely-treated experimental animals received an intraperitoneal injection of sulpiride (20, 50 or 100 mg/kg) 30 min before testing. Chronically-treated animals received sulpiride (10, 20 or 50 mg/kg) once a day for 7 or 14 consecutive days. Acute treatment with sulpiride had an obvious antiaggressive effect, with significantly decreased time devoted to "attack" and "threat" behaviour. Although time spent in "immobility" was modestly increased, the time devoted to other motor behaviour was also increased. Chronic treatment for 1 or 2 weeks did not change any behavioural category, except "immobility". The antiaggressive action of acutely administered sulpiride is interpreted as a relatively specific dopaminergic antagonist effect and not as merely a non-specific correlate of its disruptive action on motor behaviour. The possible anxiolytic action of sulpiride is also discussed.
非典型抗精神病药物舒必利是一种选择性D2拮抗剂，对中脑边缘区域具有优先作用。本研究采用基于行为学的分析方法，研究了舒必利急性和慢性治疗对雄性小鼠攻击行为的影响。由于上述中脑边缘效应，我们假设舒必利会减少“威胁”和“攻击”行为，但不会产生明显的“不动”行为。将单独饲养的白化雄性小鼠（实验动物）与“标准对手”对峙。急性治疗的实验动物在测试前30分钟腹腔注射舒必利（20、50或100毫克/千克）。慢性治疗的动物连续7天或14天每天注射一次舒必利（10、20或50毫克/千克）。舒必利急性治疗具有明显的抗攻击作用，“攻击”和“威胁”行为所用时间显著减少。虽然“不动”行为所用时间略有增加，但其他运动行为所用时间也增加了。除“不动”行为外，1或2周的慢性治疗未改变任何行为类别。急性给予舒必利的抗攻击作用被解释为相对特异性的多巴胺能拮抗剂作用，而不仅仅是其对运动行为破坏作用的非特异性关联。文中还讨论了舒必利可能的抗焦虑作用。
