Navarro J F, Miñarro J, Simón V M
Area de Psicobiología, Facultad de Psicología, Universidad de Málaga, Spain.
Physiol Behav. 1993 Jun;53(6):1055-9. doi: 10.1016/0031-9384(93)90359-n.
The study of the temporal course of tolerance development was used as a means to separate different aspects of the action of haloperidol on social behavior. Agonistic behavior was studied in isolated male mice that confronted standard opponents (anosmic and grouped conspecifics) in a neutral area. The aggressive and motor behaviors of the experimental animals were evaluated 30 min or 24 h either after a single injection of haloperidol (0.4 mg/kg) or following the last of a series of 15 or 30 injections. When animals were evaluated 30 min after the haloperidol injection, no tolerance to the antiaggressive effects was evident. The action on immobility, on the contrary, showed a clear tolerance development with repeated drug administration, both with 15 and 30 injections. When evaluated 24 h after the last injection, tolerance to the antiaggressive effects developed with repeated injections. Increased immobility was never found in the tests carried out after 24 h, not even in the single injection group. The clear divergence found in the temporal courses of tolerance to haloperidol in its antiaggressive and motor effects suggests that these actions are mediated through different neurophysiological mechanisms. A parallel with extrapyramidal and therapeutic effects is discussed.
对耐受性发展时间进程的研究被用作一种手段，以区分氟哌啶醇对社会行为作用的不同方面。在中性区域面对标准对手（无嗅觉且成群的同种个体）的单独饲养雄性小鼠中研究了攻击性行为。在单次注射氟哌啶醇（0.4mg/kg）后30分钟或24小时，或在一系列15次或30次注射中的最后一次注射后，对实验动物的攻击行为和运动行为进行评估。当在氟哌啶醇注射后30分钟对动物进行评估时，未发现对其抗攻击作用有耐受性。相反，随着药物重复给药，无论是15次还是30次注射，对不动行为的作用都显示出明显的耐受性发展。当在最后一次注射后24小时进行评估时，随着重复注射，对抗攻击作用产生了耐受性。在24小时后进行的测试中，从未发现不动行为增加，即使在单次注射组中也是如此。在氟哌啶醇的抗攻击和运动作用的耐受性时间进程中发现的明显差异表明，这些作用是通过不同的神经生理机制介导的。文中讨论了与锥体外系和治疗作用的平行关系。
