Khan Yashmin, Swain Jyoti Praksh
Chhattisgarh Institute of Medical Sciences, Bilaspur 495001.
J Indian Med Assoc. 2009 Nov;107(11):825-6.
Acquired reactive perforating collagenosis is a skin disorder characterised by the transepidermal elimination of altered collagen through the epidermis. Two distinct forms exist; an inherited form that present in childhood resulting from superficial trauma, scratching, insect bite, etc., and an acquired form that usually develops de novo in patients suffering from many chronic systemic and auto-immune diseases without any minor injury. Here a 36-year-old, insulin dependent diabetes mellitus patient with acquired variety of reactive perforating collagenosis and lipodystrophy at the sites of insulin injection sites is presented. Isotretinoin 0.1% cream was advised but with little improvement.
获得性反应性穿通性胶原病是一种皮肤疾病，其特征是通过表皮对改变的胶原蛋白进行经表皮清除。该病有两种不同的形式：一种是遗传性形式，在儿童期因浅表创伤、搔抓、昆虫叮咬等而出现；另一种是获得性形式，通常在患有许多慢性全身性和自身免疫性疾病的患者中无任何轻微损伤而新发。本文介绍了一名36岁的胰岛素依赖型糖尿病患者，在胰岛素注射部位出现了获得性多种反应性穿通性胶原病和脂肪营养不良。建议使用0.1%异维A酸乳膏，但改善甚微。
