Laboratory of Behavioral Neurogenomics, Sector of Medical Genetics, Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Prospekt Lavrentyeva 10, Novosibirsk, 630090, Russia.
Pharmacol Biochem Behav. 2010 Aug;96(2):211-6. doi: 10.1016/j.pbb.2010.05.007. Epub 2010 May 12.
Ample research indicates that age-related neuronal-behavioral decrements are the result of oxidative stress and may be ameliorated by antioxidants. Here we examined effects of mitochondria-targeted antioxidant, SkQ1, on sexual motivation in 12-month-old Wistar and accelerated-senescent OXYS male rats. A change in behavioral activity of a male at a holed transparent partition with a receptive female on the other side was taken as an index of sexual motivation. The social behavior of male in same conditions with ovariectomised (OVXed) female and castrated male was investigated to differentiate sexually and socially motivated behavior. Behavioral response to social stimulus did not depend on age and genotype. No differences were found between 4- and 12-month-old Wistar males when sexual stimulus was presented; however, 12-month-old OXYS males demonstrated a lower propensity for sexual motivation as compared to 4-month-old OXYS rats and 12-month-old Wistar rats. We examined effects of SkQ1 on sexual motivation in 12-month-old male rats following prolonged supplementation begun at 1.5months of age (10, 50 or 250nmol/kg daily), a 45-day supplementation begun at 10.5months of age (50nmol/kg) and a 3-month supplementation begun at 9months of age (250nmol/kg). SkQ1 did not affect locomotor activity; however, it increased the time spent at the partition. A significantly higher measure of the motivational stage of sexual behavior was displayed following chronic preventive treatment at a dose of 50 and 250nmol/kg by OXYS rats. Chronic therapeutic treatment during 3months at a dose of 250nmol/kg was effective in age-accelerated OXYS rats too. These findings suggest an essential role for oxidative stress associated with mitochondrial dysfunction in the decline of sexually motivated behavior of male rats. Recovery from these impairments and/or their prevention enables a fully successful performance of the initial stage of male sexual behavior.
大量研究表明，与年龄相关的神经元行为衰退是氧化应激的结果，抗氧化剂可能会改善这种情况。在这里，我们研究了靶向线粒体的抗氧化剂 SkQ1 对 12 个月大的 Wistar 和加速衰老 OXYS 雄性大鼠性动机的影响。雄性在透明隔板上的行为活动变化，当隔板另一侧有一只接受的雌性时，这被视为性动机的指标。在相同条件下，对雄性进行去卵巢（OVXed）雌性和去势雄性的社会行为研究，以区分性动机和社会动机行为。对社会刺激的行为反应不依赖于年龄和基因型。当呈现性刺激时，4 个月大和 12 个月大的 Wistar 雄性之间没有发现差异；然而，与 4 个月大的 OXYS 大鼠和 12 个月大的 Wistar 大鼠相比，12 个月大的 OXYS 雄性表现出较低的性动机倾向。我们研究了在 12 个月大的雄性大鼠中，SkQ1 对性动机的影响，这些雄性大鼠在 1.5 个月大时开始长期补充（每天 10、50 或 250nmol/kg），在 10.5 个月大时开始 45 天补充（50nmol/kg），在 9 个月大时开始 3 个月补充（250nmol/kg）。SkQ1 不影响运动活动；然而，它增加了在隔板上花费的时间。慢性预防性治疗（剂量为 50 和 250nmol/kg）可显著提高 OXYS 大鼠性行为动机阶段的测量值。在 250nmol/kg 的剂量下进行 3 个月的慢性治疗对加速衰老的 OXYS 大鼠也有效。这些发现表明，与线粒体功能障碍相关的氧化应激在雄性大鼠性动机行为下降中起着重要作用。从这些损伤中恢复和/或预防它们可以使雄性性行为的初始阶段完全成功。
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