Dixon Stacy E, Stilger Krista L, Elias Eliana V, Naguleswaran Arunasalam, Sullivan William J
Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, 46202, United States.
Mol Biochem Parasitol. 2010 Sep;173(1):1-9. doi: 10.1016/j.molbiopara.2010.05.001. Epub 2010 May 12.
In the past 10 years, the field of parasitology has witnessed an explosion of studies investigating gene regulation. In this review, we will describe recent advances largely stemming from the study of Toxoplasma gondii, a significant opportunistic pathogen and useful model for other apicomplexan protozoa. Surprising findings have emerged, including the discovery of a wealth of epigenetic machinery in these primitive eukaryotes, unusual histone variants, and a battery of plant-like transcription factors. We will elaborate on how these unusual features impact parasite physiology and potential therapeutics as we summarize some of the key discoveries from the last decade. We will close by proposing a few questions to address in the next 10 years.
在过去的十年里，寄生虫学领域见证了大量研究基因调控的研究成果涌现。在这篇综述中，我们将描述近期主要源于对弓形虫研究的进展，弓形虫是一种重要的机会性致病原，也是研究其他顶复门原生动物的有用模型。一些惊人的发现已经出现，包括在这些原始真核生物中发现了丰富的表观遗传机制、不寻常的组蛋白变体以及一系列植物样转录因子。在总结过去十年的一些关键发现时，我们将详细阐述这些不寻常的特征如何影响寄生虫的生理学和潜在治疗方法。最后，我们将提出一些未来十年需要解决的问题。
