Division of Child & Adolescent Psychiatry, Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan City, Bongmyoung Dong 23-20 Choongnam Province, 330-721, South Korea.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):974-9. doi: 10.1016/j.pnpbp.2010.05.006. Epub 2010 May 11.
Serotonergic system-related genes are likely to be involved in mechanisms underlying attention deficit hyperactivity disorder (ADHD). We investigated the association of serotonin the 1A receptor C-1019G single nucleotide polymorphism (HTR1A C-1019G SNP) and tryptophan hydroxylase 2 gene -703G/T (TPH2 -703G/T) SNP with ADHD. All of the ADHD subjects completed a comprehensive and standardized diagnostic and psychological evaluation battery including the parents' Korean version of the ADHD Rating Scale-IV (ARS). The genotype and allele frequencies of 78 ADHD patients and 107 normal controls were analyzed for 5-HTR1A C-1019G and TPH2 -703G/T. There were statistically significant differences in the genotype distributions and allele frequencies of HTR1A C-1019G between the ADHD group and the control group. The homozygous allele C frequency was significantly higher in ADHD patients than in controls. However, no differences in either genotype distribution or in allele frequencies of TPH2 -703G/T were observed between the ADHD patients and the controls. In the ADHD patients, ANCOVA revealed that there were no significant differences in the subscales and total score between the ADHD probands with the CC genotype and those with the CG and GG genotypes in ARS and the Continuous Performance Test (CPT) when adjusting for age and gender. The odds ratio comparing the CC genotype group with the CG genotype group and the C allele with G was 2.12 and 1.79 respectively. Therefore, genotype CC was associated with higher risk of ADHD. Our results suggest that the HTR1A C-1019G SNP may affect susceptibility to ADHD. Further investigation with a larger number of subjects is needed in order to confirm this finding.
5-羟色胺能系统相关基因可能参与注意缺陷多动障碍（ADHD）的发病机制。我们研究了 5-羟色胺 1A 受体 C-1019G 单核苷酸多态性（HTR1A C-1019G SNP）和色氨酸羟化酶 2 基因-703G/T（TPH2 -703G/T）SNP 与 ADHD 的相关性。所有 ADHD 患者均完成了全面、标准化的诊断和心理评估，包括父母的 ADHD 评定量表-IV（ARS）的韩文版。分析了 78 例 ADHD 患者和 107 例正常对照者 5-HTR1A C-1019G 和 TPH2 -703G/T 的基因型和等位基因频率。ADHD 组和对照组在 HTR1A C-1019G 的基因型分布和等位基因频率方面存在统计学差异。ADHD 患者的纯合子 C 等位基因频率明显高于对照组。然而，ADHD 患者与对照组之间 TPH2 -703G/T 的基因型分布或等位基因频率均无差异。在 ADHD 患者中，当调整年龄和性别后，ANCOVA 显示 ARS 和连续性能测试（CPT）中 CC 基因型和 CG 基因型及 GG 基因型 ADHD 患者的亚量表和总分之间无显著差异。与 CG 基因型组和 C 等位基因组相比，CC 基因型组的优势比分别为 2.12 和 1.79。因此，CC 基因型与 ADHD 的发病风险增加相关。我们的结果表明，HTR1A C-1019G SNP 可能影响 ADHD 的易感性。需要进一步的研究以确定这一发现。
