Park Young Hyun, Lee Kyung Kyu, Kwon Ho Jang, Ha Mina, Kim Eun Jung, Yoo Seung Jin, Paik Ki Chung, Lim Myung Ho
Environmental Health Center, Dankook Medical Hospital, Cheonan City, South Korea.
Genet Test Mol Biomarkers. 2013 Mar;17(3):178-82. doi: 10.1089/gtmb.2012.0214. Epub 2013 Jan 11.
Attention deficit hyperactivity disorder (ADHD) is a common disorder of the school age population. ADHD has been shown to be familial, and genetic studies estimate its heritability at 80%-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the HTR1A gene in Korean children with ADHD. The sample consisted of 142 ADHD children and 139 control children. We diagnosed ADHD according to the Diagnostic and Statistical Manual of Mental Disorders-4th edition. ADHD symptoms were evaluated with Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 281 subjects, DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for HTR1A polymorphism. Alleles and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of HTR1A gene polymorphism in the ADHD and control groups. This study showed that there was a significant correlation among the frequencies of the rs10042486 (OR=1.55, 95% CI=1.02-2.30, p=0.041), rs1423691(OR=1.55, 95% CI=1.02-2.30, p=0.041),and rs878567(OR=1.60, 95% CI=1.06-2.43, p=0.027) alleles of HTR1A, but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggested that HTR1A might be related to ADHD symptoms.
注意缺陷多动障碍（ADHD）是学龄儿童中的一种常见疾病。ADHD已被证明具有家族性，基因研究估计其遗传度在80%-90%。本研究的目的是调查韩国ADHD儿童中5-羟色胺受体1A（HTR1A）基因的基因类型和等位基因之间的关联。样本包括142名ADHD儿童和139名对照儿童。我们根据《精神障碍诊断与统计手册》第四版诊断ADHD。使用康纳斯父母评定量表和杜保罗父母ADHD评定量表评估ADHD症状。从281名受试者采集血样，从血淋巴细胞中提取DNA，并对HTR1A基因多态性进行聚合酶链反应。使用卡方检验比较等位基因和基因型频率。我们比较了ADHD组和对照组中HTR1A基因多态性的等位基因和基因型频率。本研究表明，HTR1A基因的rs10042486（比值比[OR]=1.55，95%置信区间[CI]=1.02-2.30，p=0.041）、rs1423691（OR=1.55，95%CI=1.02-2.30，p=0.041）和rs878567（OR=1.60，95%CI=1.06-2.43，p=0.027）等位基因频率之间存在显著相关性，但最终结论尚不明确。预计将对更大的患者群体或纯亚组进行后续研究。这些结果表明，HTR1A可能与ADHD症状有关。
