• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Frequency and rate of pilin antigenic variation of Neisseria meningitidis.脑膜炎奈瑟菌菌毛抗原变异的频率和速率。
J Bacteriol. 2010 Jul;192(14):3822-3. doi: 10.1128/JB.00280-10. Epub 2010 May 14.
2
Pilin antigenic variation occurs independently of the RecBCD pathway in Neisseria gonorrhoeae.淋球菌菌毛抗原变异独立于RecBCD途径发生。
J Bacteriol. 2009 Sep;191(18):5613-21. doi: 10.1128/JB.00535-09. Epub 2009 Jul 10.
3
Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria.聚焦同源重组：致病性奈瑟氏菌菌毛抗原变异。
Mol Microbiol. 2011 Sep;81(5):1136-43. doi: 10.1111/j.1365-2958.2011.07773.x. Epub 2011 Aug 4.
4
Analysis of Pilin Antigenic Variation in Neisseria meningitidis by Next-Generation Sequencing.利用下一代测序技术分析脑膜炎奈瑟菌的菌毛抗原变异。
J Bacteriol. 2018 Oct 23;200(22). doi: 10.1128/JB.00465-18. Print 2018 Nov 15.
5
The frequency and rate of pilin antigenic variation in Neisseria gonorrhoeae.淋病奈瑟菌菌毛抗原变异的频率和速率
Mol Microbiol. 2005 Oct;58(2):510-9. doi: 10.1111/j.1365-2958.2005.04838.x.
6
Transcription of a cis-acting, noncoding, small RNA is required for pilin antigenic variation in Neisseria gonorrhoeae.顺式作用、非编码、小 RNA 的转录是淋病奈瑟菌菌毛抗原变异所必需的。
PLoS Pathog. 2013 Jan;9(1):e1003074. doi: 10.1371/journal.ppat.1003074. Epub 2013 Jan 17.
7
A genetic screen identifies genes and sites involved in pilin antigenic variation in Neisseria gonorrhoeae.一项基因筛选鉴定出了参与淋病奈瑟菌菌毛抗原变异的基因和位点。
Mol Microbiol. 2005 Jul;57(2):468-83. doi: 10.1111/j.1365-2958.2005.04657.x.
8
Characterization of a novel antisense RNA in the major pilin locus of Neisseria meningitidis influencing antigenic variation.脑膜炎奈瑟菌主要菌毛蛋白基因座中一种影响抗原变异的新型反义RNA的特性分析
J Bacteriol. 2015 May;197(10):1757-68. doi: 10.1128/JB.00082-15. Epub 2015 Mar 9.
9
A Double-Strand Break Does Not Promote Neisseria gonorrhoeae Pilin Antigenic Variation.双链断裂不会促进淋病奈瑟菌菌毛抗原变异。
J Bacteriol. 2019 Jun 10;201(13). doi: 10.1128/JB.00256-19. Print 2019 Jul 1.
10
Antigenic variation. Modulating bacterial virulence.抗原变异。调节细菌毒力。
Nature. 1989 Apr 20;338(6217):622-3. doi: 10.1038/338622a0.

引用本文的文献

1
Maximizing bacterial survival: integrating sense-and-respond and bet-hedging mechanisms.最大化细菌存活率：整合感知与响应机制和赌局式策略机制
Trends Microbiol. 2025 Jun 18. doi: 10.1016/j.tim.2025.05.010.
2
Landmark Discoveries and Recent Advances in Type IV Pilus Research.标志性发现和 IV 型菌毛研究的最新进展。
Microbiol Mol Biol Rev. 2022 Sep 21;86(3):e0007622. doi: 10.1128/mmbr.00076-22. Epub 2022 May 25.
3
Type VI secretion system killing by commensal is influenced by expression of type four pili.共生菌通过表达 IV 型菌毛影响 VI 型分泌系统的杀伤作用。
Elife. 2021 Jul 7;10:e63755. doi: 10.7554/eLife.63755.
4
Systematic Analysis of REBASE Identifies Numerous Type I Restriction-Modification Systems with Duplicated, Distinct Specificity Genes That Can Switch System Specificity by Recombination.对REBASE的系统分析鉴定出众多具有重复、独特特异性基因的I型限制修饰系统，这些系统可通过重组切换系统特异性。
mSystems. 2020 Jul 28;5(4):e00497-20. doi: 10.1128/mSystems.00497-20.
5
Contribution of σ and σ Factors to Expression of Class II in Neisseria meningitidis.σ 和 σ 因子对脑膜炎奈瑟菌 II 类表达的贡献。
J Bacteriol. 2019 Sep 20;201(20). doi: 10.1128/JB.00170-19. Print 2019 Oct 15.
6
Analysis of Pilin Antigenic Variation in Neisseria meningitidis by Next-Generation Sequencing.利用下一代测序技术分析脑膜炎奈瑟菌的菌毛抗原变异。
J Bacteriol. 2018 Oct 23;200(22). doi: 10.1128/JB.00465-18. Print 2018 Nov 15.
7
Does DNA replication direct locus-specific recombination during host immune evasion by antigenic variation in the African trypanosome?在非洲锥虫通过抗原变异进行宿主免疫逃避的过程中，DNA复制是否指导位点特异性重组？
Curr Genet. 2017 Jun;63(3):441-449. doi: 10.1007/s00294-016-0662-7. Epub 2016 Nov 7.
8
Antigenic Variation in Bacterial Pathogens.细菌病原体中的抗原变异
Microbiol Spectr. 2016 Feb;4(1). doi: 10.1128/microbiolspec.VMBF-0005-2015.
9
An OMV Vaccine Derived from a Capsular Group B Meningococcus with Constitutive FetA Expression: Preclinical Evaluation of Immunogenicity and Toxicity.一种源自具有组成型FetA表达的B群脑膜炎球菌的外膜囊泡疫苗：免疫原性和毒性的临床前评估
PLoS One. 2015 Sep 21;10(9):e0134353. doi: 10.1371/journal.pone.0134353. eCollection 2015.
10
Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation.由序列不变菌毛蛋白组成的IV型脑膜炎奈瑟菌菌毛被多位点糖基化所掩盖。
PLoS Pathog. 2015 Sep 14;11(9):e1005162. doi: 10.1371/journal.ppat.1005162. eCollection 2015 Sep.

本文引用的文献

1
Sequence conservation of pilus subunits in Neisseria meningitidis.脑膜炎奈瑟菌菌毛亚基的序列保守性。
Vaccine. 2010 Jul 5;28(30):4817-26. doi: 10.1016/j.vaccine.2010.04.065. Epub 2010 May 8.
2
An alternative DNA structure is necessary for pilin antigenic variation in Neisseria gonorrhoeae.另一种DNA结构对于淋病奈瑟菌菌毛抗原变异是必需的。
Science. 2009 Aug 7;325(5941):764-7. doi: 10.1126/science.1175653.
3
Pilin antigenic variation occurs independently of the RecBCD pathway in Neisseria gonorrhoeae.淋球菌菌毛抗原变异独立于RecBCD途径发生。
J Bacteriol. 2009 Sep;191(18):5613-21. doi: 10.1128/JB.00535-09. Epub 2009 Jul 10.
4
Transposon mutagenesis identifies sites upstream of the Neisseria gonorrhoeae pilE gene that modulate pilin antigenic variation.转座子诱变鉴定出淋病奈瑟菌菌毛蛋白E基因上游可调节菌毛蛋白抗原变异的位点。
J Bacteriol. 2007 May;189(9):3462-70. doi: 10.1128/JB.01911-06. Epub 2007 Feb 16.
5
The frequency and rate of pilin antigenic variation in Neisseria gonorrhoeae.淋病奈瑟菌菌毛抗原变异的频率和速率
Mol Microbiol. 2005 Oct;58(2):510-9. doi: 10.1111/j.1365-2958.2005.04838.x.
6
Low-level pilin expression allows for substantial DNA transformation competence in Neisseria gonorrhoeae.低水平菌毛蛋白表达使淋病奈瑟菌具备显著的DNA转化能力。
Infect Immun. 2003 Nov;71(11):6279-91. doi: 10.1128/IAI.71.11.6279-6291.2003.
7
NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。
J Bacteriol. 1963 Jun;85(6):1274-9. doi: 10.1128/jb.85.6.1274-1279.1963.
8
Phenotypes of a naturally defective recB allele in Neisseria meningitidis clinical isolates.脑膜炎奈瑟菌临床分离株中天然缺陷型recB等位基因的表型
Infect Immun. 2002 Aug;70(8):4185-95. doi: 10.1128/IAI.70.8.4185-4195.2002.
9
Meningococcal disease.脑膜炎球菌病
N Engl J Med. 2001 May 3;344(18):1378-88. doi: 10.1056/NEJM200105033441807.
10
Insertionally inactivated and inducible recA alleles for use in Neisseria.
Gene. 1997 Apr 1;188(2):215-20. doi: 10.1016/s0378-1119(96)00810-4.

脑膜炎奈瑟菌菌毛抗原变异的频率和速率。

Frequency and rate of pilin antigenic variation of Neisseria meningitidis.

机构信息

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA.

出版信息

J Bacteriol. 2010 Jul;192(14):3822-3. doi: 10.1128/JB.00280-10. Epub 2010 May 14.

DOI:10.1128/JB.00280-10
PMID:20472803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2897326/
Abstract

The rates of pilin antigenic variation (Av) of two strains of Neisseria meningitidis were determined using an unbiased DNA sequencing assay. Strain MC58 underwent pilin Av at a rate similar to that of N. gonorrhoeae strain MS11 but lower than that of N. gonorrhoeae strain FA1090. Pilin Av was undetectable in strain FAM18.

摘要

采用无偏 DNA 测序检测了两种脑膜炎奈瑟菌菌株的菌毛抗原变异 (Av) 率。MC58 菌株的菌毛 Av 率与淋球菌 MS11 菌株相似，但低于淋球菌 FA1090 菌株。FAM18 菌株未检测到菌毛 Av。