Hughes B L, Jones J E, Toler J E, Solis J, Castaldo D J
Department of Poultry Science, Clemson University, Clemson, South Carolina 29634-0379.
Poult Sci. 1991 Mar;70(3):476-82. doi: 10.3382/ps.0700476.
Ten-mo-old broiler feeds were fed nicarbazin (NCZ) at 0, 25, 50 and 100 ppm of their diet for 2, 4, or 6 days to simulate accidental contamination of their feed with the medicant. Reduced egg production was observed in all treatments except 25 and 50 ppm NCZ for 2 days. A consistent reduction in egg weight occurred only at the maximum treatment level of 100 ppm for 6 days. Reduction in hatchability was generally evident by Days 5 and 6 of the experiment except for the lowest treatment of 25 ppm NCZ for 2 days. Due partially to the low number of eggs set, no statistically significant reduction in hatchability was seen for the group receiving 50 ppm NCZ for 4 days, but hatchability had dropped over 17 percentage points (from 93.3 to 75.5%) by Days 5 and 6 of the experiment, and continued to drop to a low of 31% on Days 11 and 12 of the experiment. Shell pigmentation was the most sensitive characteristic measured, with significant depigmentation occurring after only 2 days of feeding 25 ppm NCZ. Generally, the severity and duration of effects were in proportion to medicant concentration and length of treatment time. Fertility was not influenced by the medicant.
给10日龄的肉鸡饲料分别添加0、25、50和100 ppm的尼卡巴嗪（NCZ），持续2、4或6天，以模拟饲料意外被该药物污染的情况。除了25 ppm和50 ppm的NCZ处理2天外，所有处理组均观察到产蛋量下降。仅在最高处理水平100 ppm持续6天时，蛋重出现持续下降。除了最低处理水平25 ppm的NCZ处理2天外，在实验的第5天和第6天，孵化率普遍明显下降。部分由于入孵蛋数量较少，接受50 ppm NCZ处理4天的组未观察到孵化率有统计学意义的下降，但在实验的第5天和第6天，孵化率下降超过17个百分点（从93.3%降至75.5%），并在实验的第11天和第12天继续降至31%的低点。蛋壳色素沉着是所测最敏感的特征，在饲喂25 ppm NCZ仅2天后就出现了显著的色素脱失。一般来说，影响的严重程度和持续时间与药物浓度和处理时间长度成正比。受精率不受该药物影响。
