IOBA (Institute of Applied Opthalmobiology), Ocular Surface Group, Campus Miguel Delibes, University of Valladolid, Valladolid, Spain.
Expert Rev Clin Immunol. 2008 Jul;4(4):457-67. doi: 10.1586/1744666X.4.4.457.
Altered levels of several cytokines and chemokines have been found in different types of inflammatory ocular surface diseases, such as allergy or dry-eye syndrome. It has also been demonstrated that epithelial cells play a key role in the persistence and even initiation of chronic mucosal inflammation. The recent development of 'multiplex detection' technologies has facilitated the identification of specific patterns of expression of these molecules in some ocular immune-based inflammatory disorders. Analysis of these molecules in tissues, cells (in vivo and in vitro) and tears has revealed that not only inflammatory cells but also epithelial and fibroblast resident cells are sources of these molecules. The purpose of this review is to summarize recent studies in this field.
已经在不同类型的炎症性眼表面疾病中发现了几种细胞因子和趋化因子水平的改变，例如过敏或干眼症综合征。还已经证明上皮细胞在慢性粘膜炎症的持续甚至启动中起着关键作用。最近“多重检测”技术的发展促进了这些分子在一些基于眼部免疫的炎症性疾病中的特异性表达模式的识别。对这些分子在组织、细胞（体内和体外）和泪液中的分析表明，不仅炎症细胞，而且上皮细胞和成纤维细胞固有细胞也是这些分子的来源。本文综述了这一领域的最新研究进展。
