Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Poursina Ave, 16 Azar St. Keshavarz BLVD, 1417613151, Tehran, Iran.
Mol Biol Rep. 2013 Aug;40(8):4861-7. doi: 10.1007/s11033-013-2585-4. Epub 2013 May 6.
Graft versus host disease (GVHD) is a major complication of bone marrow transplantation (BMT). Numerous studies have shown the potential role of cytokine genotypes in the occurrence of GVHD. In this retrospective, case-control study we aimed to investigate the association between 13 cytokine genes and acute GVHD (aGVHD) after HLA-identical sibling BMT in 91 Iranian subjects. Negative association was found between aGVHD and donor IL-10/GCC haplotype or donor IL-4Ra-A allele in the population study. When compared within the leukemia subgroup, we observed positive association between recipient IL-1α -889/C allele and aGVHD. Also there were negative association between recipient IL-10/CAA haplotype and donor IL-4Ra/A allele and development of aGVHD. Among the different genotypes only donor IL-4Ra and donor IL-12 showed significant association. We conclude that several cytokine polymorphisms are positively and negatively associated with aGVHD in Iranian HLA matched siblings, of which IL-4Ra and IL-12 may play important roles.
移植物抗宿主病（GVHD）是骨髓移植（BMT）的主要并发症。许多研究表明细胞因子基因型在 GVHD 的发生中具有潜在作用。在这项回顾性病例对照研究中，我们旨在调查 91 名伊朗受试者中 13 个细胞因子基因与 HLA 相同的同胞 BMT 后急性 GVHD（aGVHD）之间的关联。在人群研究中，发现 aGVHD 与供体 IL-10/GCC 单倍型或供体 IL-4Ra-A 等位基因呈负相关。在白血病亚组内比较时，我们观察到受体 IL-1α-889/C 等位基因与 aGVHD 之间存在正相关。此外，受体 IL-10/CAA 单倍型与供体 IL-4Ra/A 等位基因与 aGVHD 的发生呈负相关。在不同的基因型中，只有供体 IL-4Ra 和供体 IL-12 表现出与 aGVHD 显著相关。我们得出结论，伊朗 HLA 匹配的同胞中，几种细胞因子多态性与 aGVHD 呈正相关和负相关，其中 IL-4Ra 和 IL-12 可能发挥重要作用。
