Department of Endodontics, University of Medical Sciences, Hamadan, Iran.
J Endod. 2010 Jun;36(6):978-81. doi: 10.1016/j.joen.2010.03.015. Epub 2010 Apr 24.
Effective management of endodontic pain represents a continuing challenge. This study evaluates the use of a preoperative, single oral dose of prednisolone for the prevention and control of postendodontic pain.
Forty patients were randomly assigned to 2 groups, placebo and prednisolone (30 mg). The medications were administered 30 minutes before the start of standard endodontic treatment. Postoperative pain was assessed after 6, 12, and 24 hours by using a visual analogue scale.
The outcome showed that prednisolone resulted in a statistically significant reduction in postendodontic pain at 6, 12, and 24 hours (P < .0001). No side effects were reported for any of the medications used.
This study suggests that a preoperative, single oral dose of prednisolone substantially reduced postendodontic pain. Further studies are needed to evaluate the applicability of these findings to other clinical conditions, single- versus multiple-visit endodontic treatment, and drug regimens.
有效管理根管治疗后的疼痛一直是个挑战。本研究评估了术前单次口服泼尼松龙预防和控制根管治疗后疼痛的效果。
40 名患者随机分为两组，安慰剂组和泼尼松龙组（30mg）。药物在标准根管治疗开始前 30 分钟给药。术后 6、12 和 24 小时使用视觉模拟评分法评估术后疼痛。
结果表明，泼尼松龙在术后 6、12 和 24 小时显著降低了根管治疗后的疼痛（P<.0001）。两种药物均未报告任何副作用。
本研究表明，术前单次口服泼尼松龙可显著减轻根管治疗后的疼痛。需要进一步研究以评估这些发现对其他临床情况、单次就诊与多次就诊根管治疗以及药物方案的适用性。
