Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Child Adolesc Psychiatr Clin N Am. 2010 Apr;19(2):301-18, ix. doi: 10.1016/j.chc.2010.01.007.
This article reviews the etiology, clinical characteristics, and treatment of inflammatory bowel disease (IBD) and associated psychological sequelae in children and adolescents with this lifelong disease. Pediatric-onset IBD, consisting of Crohn's disease and ulcerative colitis, has significant medical morbidity and in many young persons is also associated with psychological and psychosocial challenges. Depression and anxiety are particularly prevalent and have a multifaceted etiology, including IBD-related factors such as cytokines and steroids used to treat IBD and psychosocial stress. A growing number of empirically supported interventions, such as cognitive behavioral therapy, hypnosis, and educational resources, help youth and their parents cope with IBD as well as the psychological and psychosocial sequelae. While there is convincing evidence that such interventions can help improve anxiety, depression, and health-related quality of life, their effects on IBD severity and course await further study.
本文回顾了儿童和青少年中这种终身性疾病的炎症性肠病（IBD）的病因、临床特征和治疗以及相关的心理后果。儿科发病的 IBD 包括克罗恩病和溃疡性结肠炎，具有显著的医疗发病率，而且在许多年轻人中也与心理和社会心理挑战有关。抑郁和焦虑尤其普遍，且具有多方面的病因，包括与 IBD 相关的因素，如细胞因子和用于治疗 IBD 的类固醇，以及心理社会压力。越来越多的经验支持干预措施，如认知行为疗法、催眠和教育资源，帮助青少年及其父母应对 IBD 及其心理和社会心理后果。虽然有令人信服的证据表明这些干预措施可以帮助改善焦虑、抑郁和与健康相关的生活质量，但它们对 IBD 严重程度和病程的影响仍有待进一步研究。
