Crawford J D, Cadera W, Vilis T
Department of Physiology, University of Western Ontario, London, Canada.
Science. 1991 Jun 14;252(5012):1551-3. doi: 10.1126/science.2047862.
The neural integrator, which converts eye velocity signals into position signals, is central to oculomotor theory. Similar integrators are probably necessary in any neural system that changes and maintains muscular tension. The integrator for horizontal eye position is in the pons, but the locations of the vertical and torsional integrators have not been clearly defined. Recording three-dimensional eye movements in alert monkeys during microstimulation and pharmacological inactivation of midbrain sites showed that the interstitial nucleus of Cajal generates both the torsional and vertical eye position signals. Up and down signals are linked with clockwise signals in the right brain and counterclockwise signals in the left brain. This three-dimensional coordinate system achieves orthogonality and bilateral symmetry without redundancy and optimizes energy efficiency for horizontal visual scanning.
神经积分器将眼速度信号转换为位置信号，是动眼神经理论的核心。在任何改变并维持肌肉张力的神经系统中，类似的积分器可能都是必需的。水平眼位积分器位于脑桥，但垂直和扭转积分器的位置尚未明确界定。在对警觉猴子进行中脑部位微刺激和药理失活期间记录三维眼动，结果显示 Cajal 间质核产生扭转和垂直眼位信号。上下信号与右脑的顺时针信号以及左脑的逆时针信号相关联。这种三维坐标系实现了正交性和双侧对称性，没有冗余，并优化了水平视觉扫描的能量效率。
