Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Org Biomol Chem. 2010 Jun 28;8(13):3078-82. doi: 10.1039/c001117g. Epub 2010 May 18.
A facile and convenient synthesis of substituted pyridines has been developed via a one-pot multicomponent reaction of easily available 1,3-dicarbonyl compounds, aromatic aldehydes, malononitrile and alcohol in the presence of NaOH under mild conditions. A series of functionalized pyridines were thus obtained by this multicomponent reaction, in which four new bonds were formed in a highly chemo- and regioselective manner, and alcohol played dual roles as both reactant and reaction medium. Particularly valuable features of this protocol including mild conditions, simple execution, broad substrate scope, and good yields of products make it an efficient and promising synthetic strategy to build pyridine skeleton.
通过在温和条件下，NaOH 存在下，1,3-二羰基化合物、芳香醛、丙二腈和醇的一锅多组分反应，开发了一种简便合成取代吡啶的方法。通过该多组分反应，得到了一系列功能化吡啶，其中以高度化学和区域选择性方式形成了四个新键，醇起到了反应物和反应介质的双重作用。该方案的特别有价值的特点包括温和的条件、简单的执行、广泛的底物范围和良好的产物收率，使其成为构建吡啶骨架的有效和有前途的合成策略。
