Zhejiang University College of Medicine, Hangzhou, People's Republic of China.
Mol Biol Rep. 2011 Feb;38(2):873-8. doi: 10.1007/s11033-010-0179-y. Epub 2010 May 18.
Osteoarthritis (OA) is a most common multifactorial degenerative joint disease in elderly individuals. OA is affecting severely the quality of life of patients, while the causes of OA are not completely understood. Age, obesity, the female sex, and previous injury are considered as significant risk factors. Recently, increased levels of adipokines which are mainly produced by adipocytes have been detected in patients with osteoarthritis. Moreover, studies on different adipokines all reveal that they have played proinflammatory and catabolic/anabolic roles during the pathophysiology of OA. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones leptin, adiponectin, resistin and visfatin on initiation and progression of OA.
骨关节炎（OA）是一种最常见的多因素退行性关节疾病，主要影响老年人。OA 严重影响患者的生活质量，而 OA 的病因尚不完全清楚。年龄、肥胖、女性和既往损伤被认为是重要的危险因素。最近，在骨关节炎患者中检测到主要由脂肪细胞产生的脂肪因子水平升高。此外，对不同脂肪因子的研究均表明，它们在 OA 的病理生理学中发挥了促炎和分解代谢/合成代谢作用。在本综述中，我们总结了脂肪组织来源的激素瘦素、脂联素、抵抗素和内脂素对 OA 发生和进展影响的最新数据。
