Stefańska-Szachoń Eleonora, Koszela Kamil, Woldańska-Okońska Marta
Faculty of Medical and Health Sciences, Radom University, 26-600 Radom, Poland.
Department of Neuroorthopedics and Neurology Clinic and Polyclinic, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland.
J Pers Med. 2024 Nov 28;14(12):1126. doi: 10.3390/jpm14121126.
: The etiology and causes of osteoarthritis are still being studied at the cellular and molecular level by many scientists around the world. With advances in knowledge, technology, and the need for complexity, new therapeutic approaches-such as restorative medicine-are being developed to protect the patient from endoprosthesis implantation, aiming to simultaneously restore and maintain physical and psychosocial function. The purpose of this study was to evaluate the effectiveness of physiotherapy after the implantation of CD34+ stem cells into the hip joints of patients with osteoarthrosis. : The study included 71 patients, previously diagnosed with HOA (hip osteoarthritis) and undergoing CD34+ stem cell therapy followed by rehabilitation. The twelve-month prospective follow-up included 23 women and 48 men. Participants were asked to provide information, regarding the quality of their daily functioning, according to the Harris Questionnaire at four time points. : In all evaluations and groups of patients, i.e., women and men, and rehabilitated and non-rehabilitated, a significantly high improvement was noted at 3 months after the administration of CD34+ stem cells, while afterwards there was a slight decrease in the value of the results obtained at 6 months after the procedure, which improved at further stages of the study. The value of functioning on the Harris scale did not differ significantly between genders, although there was a trend of better functioning in men after one year, while it was higher in rehabilitation subjects. : Patients' daily functioning was better in the rehabilitation group, as reflected by the Harris scale. The absence of adverse symptoms and the small differences in physiotherapy results between the rehabilitated and non-rehabilitated groups testify to the high effectiveness of the stem cell therapy method.
世界各地的许多科学家仍在细胞和分子水平上研究骨关节炎的病因。随着知识、技术的进步以及对复杂性的需求，正在开发新的治疗方法，如再生医学，以保护患者免受假体植入之苦，旨在同时恢复和维持身体及心理社会功能。本研究的目的是评估将CD34+干细胞植入骨关节炎患者髋关节后物理治疗的效果。
该研究纳入了71例先前被诊断为髋骨关节炎（HOA）并接受CD34+干细胞治疗及随后康复治疗的患者。为期12个月的前瞻性随访包括23名女性和48名男性。要求参与者在四个时间点根据哈里斯问卷提供有关其日常功能质量的信息。
在所有评估以及患者组中，即女性和男性、接受康复治疗和未接受康复治疗的患者，在给予CD34+干细胞后3个月时均观察到显著的高度改善，而在此之后，术后6个月获得的结果值略有下降，在研究的进一步阶段有所改善。哈里斯量表上的功能值在性别之间没有显著差异，尽管一年后男性的功能有更好的趋势，而在接受康复治疗的受试者中更高。
根据哈里斯量表，康复组患者的日常功能更好。未出现不良症状以及康复组和未康复组之间物理治疗结果的微小差异证明了干细胞治疗方法的高效性。
