黄蜂和蚂蚁毒液中的神经毒性激肽。
Neurotoxic kinins from wasp and ant venoms.
作者信息
Piek T
机构信息
Department of Pharmacology, University of Amsterdam, The Netherlands.
出版信息
Toxicon. 1991;29(2):139-49. doi: 10.1016/0041-0101(91)90098-c.
PMID:2048133
Abstract
Kinins are polypeptides of 9-18 amino-acid residues containing a bradykinin-like sequence, in some cases as part of a molecule. The bradykinin-like sequence is either bradykinin, Hyp3-bradykinin or Thr6-bradykinin. Kinins are neurotoxic components of wasp and ant venoms, causing in the insect CNS a presynaptic block of the cholinergic transmission by means of an irreversible depletion, probably caused by a non-competitive inhibition of choline uptake.
摘要
激肽是由9 - 18个氨基酸残基组成的多肽，含有类似缓激肽的序列，在某些情况下是分子的一部分。类似缓激肽的序列为缓激肽、Hyp3 -缓激肽或Thr6 -缓激肽。激肽是黄蜂和蚂蚁毒液的神经毒性成分，通过不可逆的消耗在昆虫中枢神经系统中引起胆碱能传递的突触前阻滞，这种消耗可能是由胆碱摄取的非竞争性抑制引起的。
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