从群居黄蜂多毛蜚蠊毒液中分离出的肽组分的抗惊厥和抗焦虑活性。
Anticonvulsant and anxiolytic activity of the peptide fraction isolated from the venom of the social wasp Polybia paulista.
作者信息
do Couto Lucianna Lopes, Dos Anjos Lilian Carneiro, Araujo Maíra de Azevedo Feitosa, Mourão Cecília Alves, Schwartz Carlos Aberto, Ferreira Luzitano Brandão, Mortari Márcia Renata
机构信息
Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
出版信息
Pharmacogn Mag. 2012 Oct;8(32):292-9. doi: 10.4103/0973-1296.103657.
BACKGROUND
Arthropod venoms have attracted interest because they represent a source of neuroactive compounds that can be useful tools in neuroscience and pharmacological investigations.
OBJECTIVE
The purpose of the present work was to evaluate the anticonvulsant, anxiolytic, and behavioral effects of the peptide fraction separated from venom of the social wasp.
MATERIALS AND METHODS
The low- molecular-weight compounds of the venom were separated by ultrafiltration and the bioassays were performed to test anticonvulsant and anxiolytic effects, as well as alterations in the spontaneous behavior of the animals.
RESULTS
Intracerebroventricular injections of the compounds induced dose-dependent anticonvulsant effects and a potent anxiolytic activity. Regarding behavioral effects, no significant differences were observed in relation to the saline control group.
CONCLUSION
The low-molecular-weight compounds of the venom of Polybia paulista include neuroactive peptides that can be used as pharmacological resources for anticonvulsant and anxiolytic drug research.
背景
节肢动物毒液已引起人们的兴趣，因为它们是神经活性化合物的来源，可作为神经科学和药理学研究的有用工具。
目的
本研究的目的是评估从社会性黄蜂毒液中分离出的肽组分的抗惊厥、抗焦虑和行为效应。
材料与方法
通过超滤分离毒液中的低分子量化合物，并进行生物测定以测试抗惊厥和抗焦虑效应以及动物自发行为的改变。
结果
脑室内注射这些化合物可诱导剂量依赖性的抗惊厥效应和强大的抗焦虑活性。关于行为效应，与生理盐水对照组相比未观察到显著差异。
结论
多比娅黄蜂毒液中的低分子量化合物包括神经活性肽，可作为抗惊厥和抗焦虑药物研究的药理学资源。
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