Yokosawa N, Tsuzuki K, Syuto B, Fujii N, Kimura K, Oguma K
Department of Microbiology, Sapporo Medical College, Japan.
Toxicon. 1991;29(2):261-4. doi: 10.1016/0041-0101(91)90110-d.
Clostridium botulinum 125I-labeled Cl neurotoxin bound to NG108 hybridoma cell line. Unlabeled type Cl neurotoxin inhibited the binding of the labeled Cl toxin but neither types D nor E toxin. 125I-labeled type D neurotoxin bound to rat brain synaptosomes but did not bind to NG108 cells. It is suggested that receptors for types C and D or E toxins on neuronal cell membranes are different.
