假说：转移微环境理论能够阐释婴幼儿血管瘤的发展。
Hypothesis: the metastatic niche theory can elucidate infantile hemangioma development.
作者信息
Mihm Martin C, Nelson J Stuart
机构信息
Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114-2696, USA.
出版信息
J Cutan Pathol. 2010 Apr;37 Suppl 1(Suppl 1):83-7. doi: 10.1111/j.1600-0560.2010.01521.x.
Recent advances in the understanding of the metastatic phenomenon in cancer have led to the description of a metastatic niche. This concept describes a site prepared for the tumor cells in areas frequently associated with metastasis for the individual tumor studied. This niche is a "soil" that allows for the tumor cell or "seed" to lodge and grow. Certain aspects of the biology of infantile hemangioma cells suggest a relationship to the placenta as a possible site of origin for the hemangioma precursor cells. In this article, a relationship between the placenta, with or without a chorangioma and the hemangioma sites of localization, is hypothesized. The placenta is suggested as the site of humoral factors that prepare a niche similar to the function of malignant tumor cells. If the hypothesis proves to be valid, clues for possible treatment are outlined.
对癌症转移现象理解的最新进展已促成了转移生态位的描述。这一概念描述了在针对所研究的个体肿瘤而言常与转移相关的区域中为肿瘤细胞准备的一个位点。这个生态位是允许肿瘤细胞即“种子”着床并生长的“土壤”。婴儿血管瘤细胞生物学的某些方面提示其与胎盘存在关联，胎盘可能是血管瘤前体细胞的起源位点。在本文中，我们推测了有或无绒毛膜血管瘤的胎盘与血管瘤定位部位之间的关系。胎盘被认为是产生体液因子的部位，这些体液因子能形成一个类似于恶性肿瘤细胞功能的生态位。如果该假说被证明是正确的，那么文中还概述了可能的治疗线索。
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