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1
Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks.激光治疗后能否调节人体皮肤的伤口愈合反应并延长暴露的效果？这对脉冲染料激光与局部血管生成抑制剂联合用于治疗葡萄酒色斑胎记的意义。
Lasers Surg Med. 2008 Jan;40(1):1-5. doi: 10.1002/lsm.20599.
2
Port wine stain treated with a combination of pulsed dye laser and topical rapamycin ointment.采用脉冲染料激光和外用雷帕霉素软膏联合治疗葡萄酒色斑。
Lasers Surg Med. 2016 Feb;48(2):193-6. doi: 10.1002/lsm.22436. Epub 2015 Oct 26.
3
Observations on enhanced port wine stain blanching induced by combined pulsed dye laser and rapamycin administration.联合应用脉冲染料激光和雷帕霉素诱导鲜红斑痣褪色增强的观察
Lasers Surg Med. 2011 Dec;43(10):939-42. doi: 10.1002/lsm.21141. Epub 2011 Nov 29.
4
Delayed ulceration following combination pulse dye laser and topical sirolimus treatment for port wine birthmarks: A case series.联合脉冲染料激光和局部西罗莫司治疗葡萄酒色斑后延迟性溃疡：病例系列。
Pediatr Dermatol. 2024 Jan-Feb;41(1):108-111. doi: 10.1111/pde.15409. Epub 2023 Aug 12.
5
Port-wine stain laser treatments and novel approaches.葡萄酒色斑激光治疗及新方法。
Facial Plast Surg. 2012 Dec;28(6):611-20. doi: 10.1055/s-0032-1329936. Epub 2012 Nov 27.
6
Evaluating the efficacy and safety of topical sirolimus 0.2% cream as adjuvant therapy with pulsed dye laser for the treatment of port wine stain: A randomized, double-blind, placebo-controlled trial.评估外用西罗莫司 0.2%乳膏作为脉冲染料激光辅助治疗鲜红斑痣的疗效和安全性：一项随机、双盲、安慰剂对照试验。
J Cosmet Dermatol. 2021 Aug;20(8):2498-2506. doi: 10.1111/jocd.13867. Epub 2020 Dec 9.
7
Lasers or light sources for treating port-wine stains.用于治疗葡萄酒色斑的激光或光源。
Cochrane Database Syst Rev. 2011 Nov 9(11):CD007152. doi: 10.1002/14651858.CD007152.pub2.
8
Long-term blood vessel removal with combined laser and topical rapamycin antiangiogenic therapy: implications for effective port wine stain treatment.联合激光与局部雷帕霉素抗血管生成疗法进行长期血管清除：对鲜红斑痣有效治疗的意义
Lasers Surg Med. 2010 Feb;42(2):105-12. doi: 10.1002/lsm.20890.
9
Treatment of pulsed dye laser-resistant port wine stain birthmarks.脉冲染料激光难治性葡萄酒色斑胎记的治疗。
J Am Acad Dermatol. 2007 Oct;57(4):677-82. doi: 10.1016/j.jaad.2007.01.019. Epub 2007 Jul 19.
10
Stem cell marker upregulation in normal cutaneous vessels following pulsed-dye laser exposure and its abrogation by concurrent rapamycin administration: implications for treatment of port-wine stain birthmarks.脉冲染料激光照射后正常皮肤血管中干细胞标志物上调及雷帕霉素同时给药对其的消除作用：对葡萄酒色斑胎记治疗的意义
J Cutan Pathol. 2010 Apr;37 Suppl 1(Suppl 1):76-82. doi: 10.1111/j.1600-0560.2010.01520.x.

引用本文的文献

1
Current clinical evidence is insufficient to support HMME-PDT as the first choice of treatment for young children with port wine birthmarks.目前的临床证据不足以支持血啉甲醚光动力疗法作为治疗鲜红斑痣患儿的首选方法。
Lasers Surg Med. 2024 Apr;56(4):321-333. doi: 10.1002/lsm.23779. Epub 2024 Mar 20.
2
Japanese clinical practice guidelines for vascular anomalies 2017.2017 年日本血管异常临床实践指南。
Jpn J Radiol. 2020 Apr;38(4):287-342. doi: 10.1007/s11604-019-00885-5.
3
Japanese clinical practice guidelines for vascular anomalies 2017.《2017年日本血管异常临床实践指南》
Pediatr Int. 2020 Mar;62(3):257-304. doi: 10.1111/ped.14077. Epub 2020 Mar 22.
4
Japanese Clinical Practice Guidelines for Vascular Anomalies 2017.日本 2017 年血管异常临床实践指南
J Dermatol. 2020 May;47(5):e138-e183. doi: 10.1111/1346-8138.15189. Epub 2020 Mar 22.
5
The Pathogenesis of Port Wine Stain and Sturge Weber Syndrome: Complex Interactions between Genetic Alterations and Aberrant MAPK and PI3K Activation.葡萄酒色斑和脑面血管瘤病的发病机制：遗传改变与异常 MAPK 和 PI3K 激活之间的复杂相互作用。
Int J Mol Sci. 2019 May 7;20(9):2243. doi: 10.3390/ijms20092243.
6
Successful Treatment of Unilateral Klippel-Trenaunay Syndrome With Pulsed-Dye Laser in a 2-Week Old Infant.脉冲染料激光成功治疗2周龄婴儿单侧克-特综合征
J Lasers Med Sci. 2017 Spring;8(2):98-100. doi: 10.15171/jlms.2017.18. Epub 2017 Mar 28.
7
Histologic changes associated with talaporfin sodium-mediated photodynamic therapy in rat skin.与大鼠皮肤中替拉泊芬钠介导的光动力疗法相关的组织学变化。
Lasers Surg Med. 2017 Oct;49(8):767-772. doi: 10.1002/lsm.22677. Epub 2017 May 10.
8
The Role of Laser Speckle Imaging in Port-Wine Stain Research: Recent Advances and Opportunities.激光散斑成像在葡萄酒色斑研究中的作用：最新进展与机遇
IEEE J Sel Top Quantum Electron. 2016 May-Jun;2016(3). doi: 10.1109/JSTQE.2015.2493961. Epub 2015 Oct 26.
9
Topical rapamycin suppresses the angiogenesis pathways induced by pulsed dye laser: molecular mechanisms of inhibition of regeneration and revascularization of photocoagulated cutaneous blood vessels.局部应用雷帕霉素可抑制脉冲染料激光诱导的血管生成途径：光凝皮肤血管再生和血管形成抑制的分子机制
Lasers Surg Med. 2012 Dec;44(10):796-804. doi: 10.1002/lsm.22101. Epub 2012 Dec 4.
10
The horizon for treating cutaneous vascular lesions.治疗皮肤血管病变的前景。
Semin Cutan Med Surg. 2012 Jun;31(2):98-104. doi: 10.1016/j.sder.2012.02.001.

本文引用的文献

1
Defining the role of mTOR in cancer.确定mTOR在癌症中的作用。
Cancer Cell. 2007 Jul;12(1):9-22. doi: 10.1016/j.ccr.2007.05.008.
2
Redarkening of port-wine stains 10 years after pulsed-dye-laser treatment.脉冲染料激光治疗10年后葡萄酒色斑再次变黑
N Engl J Med. 2007 Mar 22;356(12):1235-40. doi: 10.1056/NEJMoa064329.
3
Angiogenesis as a therapeutic target.血管生成作为一种治疗靶点。
Nature. 2005 Dec 15;438(7070):967-74. doi: 10.1038/nature04483.
4
Angiogenesis in life, disease and medicine.生命、疾病与医学中的血管生成
Nature. 2005 Dec 15;438(7070):932-6. doi: 10.1038/nature04478.
5
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy.肿瘤血管正常化：抗血管生成治疗中的一个新兴概念。
Science. 2005 Jan 7;307(5706):58-62. doi: 10.1126/science.1104819.
6
TSC2 regulates VEGF through mTOR-dependent and -independent pathways.结节性硬化症复合物2（TSC2）通过mTOR依赖和非依赖途径调节血管内皮生长因子（VEGF）。
Cancer Cell. 2003 Aug;4(2):147-58. doi: 10.1016/s1535-6108(03)00187-9.
7
BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.BCR/ABL通过一条涉及磷酸肌醇3激酶和雷帕霉素哺乳动物靶点的信号通路，诱导血管内皮生长因子及其转录激活因子缺氧诱导因子-1α的表达。
Blood. 2002 Nov 15;100(10):3767-75. doi: 10.1182/blood-2002-01-0109. Epub 2002 Jul 18.
8
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor.雷帕霉素通过抗血管生成抑制原发性和转移性肿瘤生长：血管内皮生长因子的作用。
Nat Med. 2002 Feb;8(2):128-35. doi: 10.1038/nm0202-128.
9
Port-wine stains unresponsive to pulsed dye laser: explanations and solutions.对脉冲染料激光无反应的葡萄酒色斑：解释与解决方案。
Br J Dermatol. 1998 Aug;139(2):173-7. doi: 10.1046/j.1365-2133.1998.02351.x.
10
Effect of the timing of treatment of port-wine stains with the flash-lamp-pumped pulsed-dye laser.闪光灯泵浦脉冲染料激光治疗葡萄酒色斑的治疗时机效果
N Engl J Med. 1998 Apr 9;338(15):1028-33. doi: 10.1056/NEJM199804093381504.

Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks.

作者信息

Phung Thuy L, Oble Darryl A, Jia Wangcun, Benjamin Laura E, Mihm Martin C, Nelson J Stuart

机构信息

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts,USA.

出版信息

Lasers Surg Med. 2008 Jan;40(1):1-5. doi: 10.1002/lsm.20599.

DOI:10.1002/lsm.20599
PMID:18220264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3496566/
Abstract
摘要