Section of Perinatal Pathology, Department of Pathology, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
BMJ Open. 2017 Sep 3;7(9):e015539. doi: 10.1136/bmjopen-2016-015539.
Placenta or placental chorangioma could be the origin site of infantile haemangioma since they share various histochemical and genetic characteristics with placental vascular tissue. The aim of the current study was to investigate the association between chorangiomas and infantile haemangiomas in singleton and multiple pregnancies.
An informative questionnaire enquiring about the presence or not of infantile haemangioma and including illustrative photos of haemangioma was sent to 469 (153 cases with chorangioma and 316 controls) mothers of 323 singleton (104 cases and 219 controls) and 146 multiple (49 cases and 97 controls) liveborn neonates registered in Sweden. Overall, 310 mothers (66.1%) from 216 singleton and 94 multiple pregnancies (96 cases and 214 controls) provided feedback and their consent to participate in the current case-control study.
The incidence of infantile haemangioma showed no statistically significant differences between cases and controls (18.8% vs 18.2%) or between singleton and multiple pregnancies (18.9% vs 17.0%). The frequency of pre-eclampsia was significantly higher in cases with chorangioma compared with controls (41.7% vs 24.3%, OR=2.22, 95% CI 1.33 to 3.71, p=0.0022) and in singleton compared with multiple pregnancies (33.3% vs 21.3%, OR=1.85, 95% CI 1.04 to 3.26, p=0.034), whereas there were no significant differences in the incidence of infantile haemangioma in neonates of mothers with or without pre-eclampsia or in neonates of mothers with multiple compared with singleton pregnancies.
There was no association between placental chorangiomas and infantile haemangiomas. Multiple pregnancies or pre-eclampsia were not significantly related to higher incidence of infantile haemangioma.
胎盘或胎盘绒毛膜血管瘤与胎盘血管组织具有各种组织化学和遗传特征，因此可能是婴儿血管瘤的起源部位。本研究旨在探讨单胎和多胎妊娠中绒毛膜血管瘤与婴儿血管瘤之间的关系。
向瑞典登记的 323 例单胎（104 例有绒毛膜血管瘤，219 例无）和 146 例多胎（49 例有绒毛膜血管瘤，97 例无）活产新生儿的 469 位母亲（153 例有绒毛膜血管瘤，316 例无）发送了一份包含婴儿血管瘤图片的有说明的调查问卷，询问其是否存在婴儿血管瘤。共有 310 位母亲（216 例单胎妊娠中的 104 例和 94 例多胎妊娠中的 97 例）反馈并同意参与当前的病例对照研究。
病例组和对照组（18.8% 对 18.2%）或单胎妊娠和多胎妊娠（18.9% 对 17.0%）之间婴儿血管瘤的发生率无统计学差异。绒毛膜血管瘤病例组母亲的子痫前期发生率明显高于对照组（41.7% 对 24.3%，OR=2.22，95%CI 1.33 至 3.71，p=0.0022）和单胎妊娠组（33.3% 对 21.3%，OR=1.85，95%CI 1.04 至 3.26，p=0.034），而子痫前期母亲所生婴儿或多胎妊娠母亲所生婴儿的婴儿血管瘤发生率无显著差异。
胎盘绒毛膜血管瘤与婴儿血管瘤之间无关联。多胎妊娠或子痫前期与婴儿血管瘤发生率升高无显著相关性。
