Department of Vector Biology and Control,State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
BMC Infect Dis. 2010 May 20;10:121. doi: 10.1186/1471-2334-10-121.
Bartonella infections are emerging in the Zhejiang Province of China. However, there has been no effort to date to explore the epidemiology of these infections in this region, nor to identify risk factors associated with exposure to Bartonella. The aim of this study was to investigate the seroprevalence of Bartonella in both patients bitten by dogs and blood donors (for control) in Eastern China, and to identify risk factors associated with exposure to Bartonella. As no previous data for this region have been published, this study will provide baseline data useful for Bartonella infection surveillance, control, and prevention.
Blood samples were collected from industrial rabies clinic attendees and blood donors living in eight areas of the Zhejiang Province of China, between December 2005 and November 2006. An indirect immunofluorescent antibody test was used to determine the presence of Bartonella in these samples. Risk factors associated with Bartonella exposure were explored using Chi-square tests and logistic regression analysis of epidemiological data relating to the study's participants.
Bartonella antibodies were detected in 19.60% (109/556) of blood samples. Seroprevalence varied among the eight areas surveys, ranging from over 32% in Hangzhou to only 2% in Jiangshan (X2 = 28.22, P < 0.001). We detected a significantly higher prevalence of Bartonella antibodies in people who had been bitten by dogs than in blood donors (X2 = 13.86, P < 0.001). Seroprevalence of Bartonella was similar among males (18.61%, n = 317) and females (20.92%, n = 239).
Bartonella antibodies were encountered in people living across Zhejiang Province and the seropositivity rate among those exposed to dog bites was significantly higher than that among blood donors, indicating that dog bites may be a risk factor for Bartonella infection.
巴通体感染在中国浙江省流行。然而，迄今为止，尚未有研究探索该地区此类感染的流行病学情况，也未确定与巴通体暴露相关的危险因素。本研究的目的是调查华东地区被狗咬伤的患者和献血者（对照）的巴通体血清流行率，并确定与巴通体暴露相关的危险因素。由于该地区尚无先前的数据发表，因此本研究将提供巴通体感染监测、控制和预防的基线数据。
2005 年 12 月至 2006 年 11 月，采集来自中国浙江省 8 个地区的工业狂犬病诊所就诊者和献血者的血液样本。采用间接免疫荧光抗体试验检测这些样本中是否存在巴通体。采用卡方检验和对研究参与者的流行病学数据进行 logistic 回归分析，探讨与巴通体暴露相关的危险因素。
在 556 份血样中，检测到巴通体抗体的占 19.60%（109/556）。8 个地区的血清流行率不同，杭州地区超过 32%，而江山市仅为 2%（X2=28.22，P<0.001）。与献血者相比，被狗咬伤的人群中巴通体抗体的阳性率显著更高（X2=13.86，P<0.001）。男性（18.61%，n=317）和女性（20.92%，n=239）的巴通体血清流行率相似。
在浙江省各地的人群中均发现了巴通体抗体，且与献血者相比，被狗咬伤的人群的阳性率显著更高，这表明狗咬伤可能是巴通体感染的一个危险因素。
