Laboratory of Human Reproduction, Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion 71003, Greece.
Reprod Biomed Online. 2007;14 Spec No 1:75-82. doi: 10.1016/S1472-6483(10)61461-7.
Successful embryo implantation in mammals requires the co-ordinated development of a blastocyst competent to implant and an adhesive endometrium. Given the indispensable role of implantation for the furtherance of the species, a number of molecular mechanisms have evolved to regulate the process. A variety of molecules, produced by embryo as well as maternal tissue participates in the cross-talk between the implanting blastocyst and the endometrium. The interplay between the various molecules and the routes in which they are involved is beginning to be elucidated. Because impaired implantation represents the most important limiting factor in the establishment of pregnancy, it is believed that research in the field will allow clinicians to improve the respective rates. This paper reviews certain groups of molecules that are considered to have key roles in the mechanisms of implantation.
哺乳动物的胚胎着床成功需要具备着床能力的囊胚和具有黏附能力的子宫内膜的协调发育。鉴于着床对于物种延续的不可或缺的作用，许多分子机制已经进化来调节这个过程。胚胎和母体组织产生的各种分子参与着床囊胚和子宫内膜之间的相互作用。各种分子之间的相互作用以及它们所涉及的途径开始被阐明。因为着床受损是妊娠建立的最重要的限制因素，人们相信该领域的研究将使临床医生能够提高各自的成功率。本文综述了某些被认为在着床机制中具有关键作用的分子群。
