Division of Cardiology and UNC McAllister Heart Institute, 8200 Medical Biomolecular Research Building, University of North Carolina, Chapel Hill, NC 27599-7126, USA.
Sci Signal. 2010 May 18;3(122):pe17. doi: 10.1126/scisignal.3122pe17.
A healthy vasculature is an essential component of development and is regulated by different signaling pathways. One of the most critical pathways involved is the vascular endothelial growth factor (VEGF) pathway. Components of this pathway serve as the first marker of primitive endothelial cells and are instrumental in inducing the initial differentiation of endothelial cells and later refining them into either arteries or veins. However, the regulation of VEGF signaling remains a mystery, with most studies focusing on the downstream components of this signaling cascade. New evidence shows that the protein cerebral cavernous malformation 3 (CCM3) is a key regulator of the VEGF pathway, bringing to light a previously unknown component of the VEGF signaling axis and opening the door to an exciting new era of vasculogenic research.
健康的脉管系统是发育的重要组成部分，受不同信号通路的调节。其中一个最重要的途径是血管内皮生长因子（VEGF）途径。该途径的组成部分是原始内皮细胞的第一个标志物，有助于诱导内皮细胞的初始分化，并随后将其细化为动脉或静脉。然而，VEGF 信号的调节仍然是一个谜，大多数研究都集中在该信号级联的下游成分上。新的证据表明，蛋白脑海绵状血管畸形 3（CCM3）是 VEGF 途径的关键调节剂，揭示了 VEGF 信号轴的一个以前未知的成分，并为血管生成研究的一个令人兴奋的新时代打开了大门。
