Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
Diabetes Care. 2010 Aug;33(8):1831-3. doi: 10.2337/dc10-0515. Epub 2010 May 18.
To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition.
A randomized clinical trial was performed to create contrasting sex steroid levels in healthy young men: by letrozole (aromatase inhibitor) to lower estradiol (E(2)) and increase testosterone (group T, n = 10) versus letrozole plus E(2) patches to lower T and raise E(2) (group E, n = 10). Mixed meals and hyperinsulinemic-euglycemic clamps were performed before and after a 1-week treatment period.
Following intervention, the postprandial triglyceride response displayed a diverging response with a decline in group T and an increase in group E; the postprandial glucose-dependent insulinotropic polypeptide (GIP) response increased in group T. Insulin sensitivity increased in group T but remained unaltered in group E.
In healthy young men, short-term changes in sex steroids affect postprandial triglyceride and GIP response and insulin sensitivity.
评估非禁食和禁食条件下性激素对代谢的影响，而不受身体成分变化的影响。
进行了一项随机临床试验，以在健康年轻男性中产生对比性激素水平：通过来曲唑（芳香酶抑制剂）降低雌二醇（E（2））并增加睾丸激素（组 T，n = 10），与来曲唑加 E（2）贴片降低睾丸激素并提高 E（2）（组 E，n = 10）。在治疗前和治疗后 1 周进行混合餐和高胰岛素-正葡萄糖钳夹。
干预后，餐后甘油三酯反应显示出不同的反应，组 T 下降，组 E 上升；组 T 中的葡萄糖依赖性胰岛素释放肽（GIP）反应增加。组 T 中的胰岛素敏感性增加，但组 E 中未改变。
在健康的年轻男性中，性激素的短期变化会影响餐后甘油三酯和 GIP 反应以及胰岛素敏感性。
