Cajaiba Mariana M, Goodman Mark A, Fuhrer Kimberly A, Rao Uma N M
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Int J Surg Pathol. 2010 Oct;18(5):319-23. doi: 10.1177/1066896910367650. Epub 2010 May 18.
The transcription factor Sox9 is known to play a crucial role in normal chondrogenesis, and antibodies against Sox9 have been proposed as a diagnostic tool for neoplasms with chondroid differentiation. However, the pattern of Sox9 immunohistochemical expression by other bone and soft tissue neoplasms, as well as its diagnostic specificity, remain unexplored. The authors have performed immunohistochemistry with antibodies against Sox9 in 106 chondroid and nonchondroid bone and soft tissue neoplasms. Moderate to intense Sox9 nuclear staining was observed in 14/20 chondrosarcomas (70%), and in 24/81 (29.6%) cases from a multitumor tissue microarray, which included 16/18 synovial sarcomas, 4/15 osteosarcomas, 2/5 peripheral primitive neuroectodermal tumor (PNET)/Ewing sarcomas, 1/1 mesenchymal chondrosarcoma, and 1/1 chondroblastoma. The results suggest that Sox9 usefulness in the diagnosis of chondroid tumors may be limited because of low sensitivity and specificity. The finding of Sox9 expression by 88.9% of synovial sarcomas represents a novel and striking observation, which deserves further investigation.
已知转录因子Sox9在正常软骨形成中起关键作用，抗Sox9抗体已被提议作为软骨样分化肿瘤的诊断工具。然而，其他骨和软组织肿瘤中Sox9免疫组化表达模式及其诊断特异性仍未得到探索。作者对106例软骨样和非软骨样骨及软组织肿瘤进行了抗Sox9抗体的免疫组化检测。在20例软骨肉瘤中的14例（70%）以及来自多肿瘤组织芯片的81例病例中的24例（29.6%）观察到中度至强烈的Sox9核染色，其中包括18例滑膜肉瘤中的16例、15例骨肉瘤中的4例、5例外周原始神经外胚层肿瘤（PNET）/尤文肉瘤中的2例、1例间叶性软骨肉瘤和1例软骨母细胞瘤。结果表明，由于敏感性和特异性较低，Sox9在软骨样肿瘤诊断中的实用性可能有限。88.9%的滑膜肉瘤中发现Sox9表达是一个新颖且引人注目的观察结果，值得进一步研究。
